Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis.

Murata, Yoko; Song, Michael; Kikuchi, Hisayuki; Hisamichi, Katsuya; Xu, Xie L; Greenspan, Andrew; Kato, Mai; Chiou, Chiun-Fang; Kato, Takeshi; Guzzo, Cynthia; Thurmond, Robin L; Ohtsuki, Mamitaro; Furue, Masutaka

Murata, Yoko; Song, Michael; Kikuchi, Hisayuki; Hisamichi, Katsuya; Xu, Xie L; Greenspan, Andrew; Kato, Mai; Chiou, Chiun-Fang; Kato, Takeshi; Guzzo, Cynthia; Thurmond, Robin L; Ohtsuki, Mamitaro; Furue, Masutaka.

Affiliation

Murata Y; Research & Development, Janssen Pharmaceutical KK, Tokyo, Japan.

J Dermatol ; 42(2): 129-39, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25491792

Subject(s)

Dermatitis, Atopic/drug therapy; Histamine Agonists/therapeutic use; Neutropenia/chemically induced; Pyrimidines/therapeutic use; Pyrrolidines/therapeutic use; Receptors, G-Protein-Coupled/antagonists & inhibitors; Adult; Double-Blind Method; Early Termination of Clinical Trials; Female; Histamine Agonists/adverse effects; Humans; Japan; Male; Pruritus/drug therapy; Pyrimidines/adverse effects; Pyrrolidines/adverse effects; Receptors, Histamine; Receptors, Histamine H4; Severity of Illness Index; Young Adult

Key words

H4 receptor; Japan; atopic dermatitis; itch

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Pyrimidines / Pyrrolidines / Histamine Agonists / Receptors, G-Protein-Coupled / Dermatitis, Atopic / Neutropenia Type of study: Clinical_trials Aspects: Patient_preference Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: J Dermatol Year: 2015 Document type: Article

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