Statin treatment is associated with improved prognosis in patients with AF-related stroke.
Int J Cardiol
; 177(1): 129-33, 2014 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-25499356
ABSTRACT
BACKGROUND/OBJECTIVES:
The most recent ACC/AHA guidelines recommend high-intensity statin therapy in ischemic stroke patients of presumably atherosclerotic origin. On the contrary, there is no specific recommendation for the use of statin in patients with non-atherosclerotic stroke, e.g. strokes related to atrial fibrillation (AF). We investigated whether statin treatment in patients with AF-related stroke is associated with improved survival and reduced risk for stroke recurrence and future cardiovascular events.METHODS:
All consecutive patients registered in the Athens Stroke Registry with AF-related stroke and no history of coronary artery disease nor clinically manifest peripheral artery disease were included in the analysis and categorized in two groups depending on whether statin was prescribed at discharge. The primary outcome was overall mortality; the secondary outcomes were stroke recurrence and a composite cardiovascular endpoint comprising of recurrent stroke, myocardial infarction, aortic aneurysm rupture or sudden cardiac death during the 5-year follow-up.RESULTS:
Among 1602 stroke patients, 404 (25.2%) with AF-related stroke were included in the analysis, of whom 102 (25.2%) were discharged on statin. On multivariate Cox-proportional-hazards model, statin treatment was independently associated with a lower mortality (hazard-ratio (HR) 0.49, 95%CI0.26-0.92) and lower risk for the composite cardiovascular endpoint during the median 22 months follow-up (HR 0.44, 95%CI0.22-0.88), but not with stroke recurrence (HR 0.47, 95%CI0.22-1.01, p 0.053).CONCLUSIONS:
In this long-term registry of patients with AF-related stroke, statin treatment was associated with improved survival and reduced risk for future cardiovascular events.Key words
Full text:
1
Collection:
01-internacional
Health context:
6_ODS3_enfermedades_notrasmisibles
Database:
MEDLINE
Main subject:
Atrial Fibrillation
/
Brain Ischemia
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Type of study:
Etiology_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Int J Cardiol
Year:
2014
Document type:
Article