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Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.
Dirat, Béatrice; Ader, Isabelle; Golzio, Muriel; Massa, Fabienne; Mettouchi, Amel; Laurent, Kathiane; Larbret, Frédéric; Malavaud, Bernard; Cormont, Mireille; Lemichez, Emmanuel; Cuvillier, Olivier; Tanti, Jean François; Bost, Frédéric.
Affiliation
  • Dirat B; INSERM, C3M, U1065, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France. Univ. Nice Sophia Antipolis, C3M, U1065, Nice, France.
  • Ader I; CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France. Université de Toulouse, UPS, IPBS, Toulouse, France.
  • Golzio M; CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France. Université de Toulouse, UPS, IPBS, Toulouse, France.
  • Massa F; INSERM, C3M, U1065, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France. Univ. Nice Sophia Antipolis, C3M, U1065, Nice, France.
  • Mettouchi A; Univ. Nice Sophia Antipolis, C3M, U1065, Nice, France. INSERM, C3M, U1065, Equipe Labellisée Ligue Contre le Cancer, Team Microtoxins in Host Pathogens Interactions, Nice, France.
  • Laurent K; INSERM, C3M, U1065, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France. Univ. Nice Sophia Antipolis, C3M, U1065, Nice, France.
  • Larbret F; University of Nice Sophia Antipolis, EA6302, Flow Cytometry Facility, Hôpital l'Archet 1, Nice, France.
  • Malavaud B; CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France. Université de Toulouse, UPS, IPBS, Toulouse, France. Hôpital Rangueil, Service d'Urologie et de Transplantation Rénale, Toulouse, France.
  • Cormont M; INSERM, C3M, U1065, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France. Univ. Nice Sophia Antipolis, C3M, U1065, Nice, France.
  • Lemichez E; Univ. Nice Sophia Antipolis, C3M, U1065, Nice, France. INSERM, C3M, U1065, Equipe Labellisée Ligue Contre le Cancer, Team Microtoxins in Host Pathogens Interactions, Nice, France.
  • Cuvillier O; CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France. Université de Toulouse, UPS, IPBS, Toulouse, France.
  • Tanti JF; INSERM, C3M, U1065, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France. Univ. Nice Sophia Antipolis, C3M, U1065, Nice, France.
  • Bost F; INSERM, C3M, U1065, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France. Univ. Nice Sophia Antipolis, C3M, U1065, Nice, France. bost@unice.fr.
Mol Cancer Ther ; 14(2): 586-96, 2015 Feb.
Article in En | MEDLINE | ID: mdl-25527635

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Cell Movement / Rac1 GTP-Binding Protein / Metformin Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Mol Cancer Ther Year: 2015 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Cell Movement / Rac1 GTP-Binding Protein / Metformin Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Mol Cancer Ther Year: 2015 Document type: Article