Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation.

Breit, Andreas; Besik, Valeria; Solinski, Hans Jürgen; Muehlich, Susanne; Glas, Evi; Yarwood, Stephen J; Gudermann, Thomas

Breit, Andreas; Besik, Valeria; Solinski, Hans Jürgen; Muehlich, Susanne; Glas, Evi; Yarwood, Stephen J; Gudermann, Thomas.

Affiliation

Breit A; Walther-Straub-Institut für Pharmakologie und Toxikologie (A.B., V.B., H.J.S., S.M., E.G., T.G.), Ludwig-Maximilians-Universität München, München, Germany 80336; and The Institute of Molecular, Cell and Systems Biology (S.J.Y.), College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow GC12 8QQ, United Kingdom.

Mol Endocrinol ; 29(3): 445-59, 2015 Mar.

Article in En | MEDLINE | ID: mdl-25584415

Subject(s)

Hypothalamus/metabolism; Phosphoserine/metabolism; Phosphotyrosine/metabolism; STAT3 Transcription Factor/metabolism; Animals; Bradykinin/pharmacology; Cell Line; Epidermal Growth Factor/pharmacology; ErbB Receptors/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Genes, Reporter; Humans; Interferon-gamma/pharmacology; Ligands; Melanocyte-Stimulating Hormones/pharmacology; Mice; Neurons/drug effects; Neurons/metabolism; Neuropeptide Y/metabolism; Phosphorylation/drug effects; Promoter Regions, Genetic/genetics; Receptors, Cytokine/metabolism; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins/metabolism; Thyrotropin-Releasing Hormone/genetics; Thyrotropin-Releasing Hormone/metabolism; Transcriptional Activation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoserine / Phosphotyrosine / STAT3 Transcription Factor / Hypothalamus Limits: Animals / Humans Language: En Journal: Mol Endocrinol Year: 2015 Document type: Article

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