The combination of ISCOMATRIX adjuvant and TLR agonists induces regression of established solid tumors in vivo.

Silva, Anabel; Mount, Adele; Krstevska, Karoline; Pejoski, David; Hardy, Matthew P; Owczarek, Catherine; Scotney, Pierre; Maraskovsky, Eugene; Baz Morelli, Adriana

Silva, Anabel; Mount, Adele; Krstevska, Karoline; Pejoski, David; Hardy, Matthew P; Owczarek, Catherine; Scotney, Pierre; Maraskovsky, Eugene; Baz Morelli, Adriana.

Affiliation

Silva A; CSL Ltd., Bio21 Institute, Melbourne, Victoria 3010, Australia.
Mount A; CSL Ltd., Bio21 Institute, Melbourne, Victoria 3010, Australia.
Krstevska K; CSL Ltd., Bio21 Institute, Melbourne, Victoria 3010, Australia.
Pejoski D; CSL Ltd., Bio21 Institute, Melbourne, Victoria 3010, Australia.
Hardy MP; CSL Ltd., Bio21 Institute, Melbourne, Victoria 3010, Australia.
Owczarek C; CSL Ltd., Bio21 Institute, Melbourne, Victoria 3010, Australia.
Scotney P; CSL Ltd., Bio21 Institute, Melbourne, Victoria 3010, Australia.
Maraskovsky E; CSL Ltd., Bio21 Institute, Melbourne, Victoria 3010, Australia.
Baz Morelli A; CSL Ltd., Bio21 Institute, Melbourne, Victoria 3010, Australia adriana.bazmorelli@csl.com.au.

J Immunol ; 194(5): 2199-207, 2015 Mar 01.

Article in En | MEDLINE | ID: mdl-25646304

Subject(s)

CD8-Positive T-Lymphocytes/drug effects; Cancer Vaccines/administration & dosage; Cholesterol/administration & dosage; Melanoma, Experimental/therapy; Pancreatic Neoplasms/therapy; Phospholipids/administration & dosage; Prostatic Neoplasms/therapy; Saponins/administration & dosage; Skin Neoplasms/therapy; Adjuvants, Immunologic/administration & dosage; Animals; CD8-Positive T-Lymphocytes/immunology; Cytotoxicity, Immunologic; Drug Combinations; Humans; Immunotherapy/methods; Male; Melanoma, Experimental/genetics; Melanoma, Experimental/immunology; Melanoma, Experimental/mortality; Mice; Mice, Knockout; Neoplasm Transplantation; Oligodeoxyribonucleotides/pharmacology; Pancreatic Neoplasms/genetics; Pancreatic Neoplasms/immunology; Pancreatic Neoplasms/mortality; Poly I-C/pharmacology; Prostatic Neoplasms/genetics; Prostatic Neoplasms/immunology; Prostatic Neoplasms/mortality; Skin Neoplasms/genetics; Skin Neoplasms/immunology; Skin Neoplasms/mortality; Survival Analysis; Toll-Like Receptor 3/antagonists & inhibitors; Toll-Like Receptor 3/genetics; Toll-Like Receptor 3/immunology; Toll-Like Receptor 9/antagonists & inhibitors; Toll-Like Receptor 9/genetics; Toll-Like Receptor 9/immunology; Tumor Burden/drug effects

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Pancreatic Neoplasms / Phospholipids / Prostatic Neoplasms / Saponins / Skin Neoplasms / Melanoma, Experimental / Cholesterol / CD8-Positive T-Lymphocytes / Cancer Vaccines Language: En Journal: J Immunol Year: 2015 Document type: Article

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