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Dose-limiting inhibition of acetylcholinesterase by ladostigil results from the rapid formation and fast hydrolysis of the drug-enzyme complex formed by its major metabolite, R-MCPAI.
Moradov, Dorit; Finkin-Groner, Efrat; Bejar, Corina; Sunita, Priyashree; Schorer-Apelbaum, Donna; Barasch, Dinorah; Nemirovski, Alina; Cohen, Marganit; Weinstock, Marta.
Affiliation
  • Moradov D; Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Finkin-Groner E; Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Bejar C; Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Sunita P; Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Schorer-Apelbaum D; Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Barasch D; Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Nemirovski A; Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Cohen M; Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Weinstock M; Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: martar@ekmd.huji.ac.il.
Biochem Pharmacol ; 94(2): 164-72, 2015 Mar 15.
Article in En | MEDLINE | ID: mdl-25662585
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholinesterase / Cholinesterase Inhibitors / Indans Limits: Animals Language: En Journal: Biochem Pharmacol Year: 2015 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholinesterase / Cholinesterase Inhibitors / Indans Limits: Animals Language: En Journal: Biochem Pharmacol Year: 2015 Document type: Article