Age influences the clinical significance of atypical glandular cells on cytology.
Anticancer Res
; 35(2): 913-9, 2015 Feb.
Article
in En
| MEDLINE
| ID: mdl-25667474
ABSTRACT
AIM:
To evaluate women with atypical glandular cells (AGC) or adenocarcinoma in situ (AIS) on cytology. PATIENTS ANDMETHODS:
Population-based data of cervical smears taken between 2008-2012 were analyzed.RESULTS:
Cancer was diagnosed in 107 out of 199 patients (54%) with AGC or AIS; 30 with cervical adenocarcinoma and 77 with endometrial cancer. All women with endometrial cancer were 50 years or older. In women younger than 50 years, cervical pre-cancerous lesions were found in 44 (47%) and cervical adenocarcinoma in 24 out of 92 cases (26%). High-risk HPV infection was found in 62 out of 103 women (60%). The detection rate of high-risk HPV at finding histopathological AGC, AIS, low-grade squamous intraepithelial lesions, high-grade squamous intraepithelial lesions or cervical cancer was 98% (95% confidence interval=0.903-1.000) (54/55).CONCLUSION:
AGC or AIS indicates endometrial neoplasia in women 50 years or older and pre-cancerous or invasive glandular cervical lesions in younger women. HPV testing seems to identify underlying cervical adenocarcinoma and high grade squamous intraepithelial lesions.Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Precancerous Conditions
/
Adenocarcinoma
/
Uterine Cervical Neoplasms
/
Age Factors
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Anticancer Res
Year:
2015
Document type:
Article