The inhibition of alpha 1-adrenoceptor-mediated contractions of rabbit pulmonary artery by Ca2+-withdrawal, pertussis toxin and N-ethylmaleimide is dependent on agonist intrinsic efficacy.

Liebau, S; Hohlfeld, J; Förstermann, U

Liebau, S; Hohlfeld, J; Förstermann, U.

Affiliation

Liebau S; Department of Clinical Pharmacology, Hannover Medical School, Federal Republic of Germany.

Naunyn Schmiedebergs Arch Pharmacol ; 339(5): 496-502, 1989 May.

Article in En | MEDLINE | ID: mdl-2570359

Subject(s)

Calcium/physiology; Ethylmaleimide/pharmacology; Muscle, Smooth, Vascular/drug effects; Pertussis Toxin; Receptors, Adrenergic, alpha/drug effects; Virulence Factors, Bordetella/pharmacology; Adrenergic alpha-Agonists/pharmacology; Animals; Azepines/pharmacology; Calcium Channel Blockers/pharmacology; Clonidine/analogs & derivatives; Clonidine/pharmacology; Female; Gallic Acid/analogs & derivatives; Gallic Acid/pharmacology; In Vitro Techniques; Male; Methoxamine/pharmacology; Muscle Contraction/drug effects; Phenylephrine/pharmacology; Pulmonary Artery/drug effects; Rabbits

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Collection: 01-internacional Database: MEDLINE Main subject: Virulence Factors, Bordetella / Calcium / Receptors, Adrenergic, alpha / Pertussis Toxin / Ethylmaleimide / Muscle, Smooth, Vascular Limits: Animals Language: En Journal: Naunyn Schmiedebergs Arch Pharmacol Year: 1989 Document type: Article

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