Pathogenicity of lupus anti-ribosomal P antibodies: role of cross-reacting neuronal surface P antigen in glutamatergic transmission and plasticity in a mouse model.

Segovia-Miranda, Fabián; Serrano, Felipe; Dyrda, Agnieszka; Ampuero, Estibaliz; Retamal, Claudio; Bravo-Zehnder, Marcela; Parodi, Jorge; Zamorano, Pedro; Valenzuela, David; Massardo, Loreto; van Zundert, Brigitte; Inestrosa, Nibaldo C; González, Alfonso

Segovia-Miranda, Fabián; Serrano, Felipe; Dyrda, Agnieszka; Ampuero, Estibaliz; Retamal, Claudio; Bravo-Zehnder, Marcela; Parodi, Jorge; Zamorano, Pedro; Valenzuela, David; Massardo, Loreto; van Zundert, Brigitte; Inestrosa, Nibaldo C; González, Alfonso.

Affiliation

Segovia-Miranda F; Pontificia Universidad Católica de Chile, Santiago, Chile.
Serrano F; Pontificia Universidad Católica de Chile, Santiago, Chile.
Dyrda A; Universidad Andrés Bello, Santiago, Chile.
Ampuero E; Universidad Andrés Bello, Santiago, Chile.
Retamal C; Pontificia Universidad Católica de Chile, Santiago, Chile.
Bravo-Zehnder M; Pontificia Universidad Católica de Chile, Santiago, Chile.
Parodi J; Universidad Católica de Temuco, Temuco, Chile.
Zamorano P; Pontificia Universidad Católica de Chile, Santiago, Chile.
Valenzuela D; Regeneron Pharmaceuticals, New York, New York.
Massardo L; Pontificia Universidad Católica de Chile, Santiago, Chile.
van Zundert B; Universidad Andrés Bello, Santiago, Chile.
Inestrosa NC; Pontificia Universidad Católica de Chile, Santiago, Chile, and Universidad de Magallanes, Punta Arenas, Chile.
González A; Pontificia Universidad Católica de Chile, Santiago, Chile, and Universidad de Magallanes, Punta Arenas, Chile.

Arthritis Rheumatol ; 67(6): 1598-610, 2015 Jun.

Article in En | MEDLINE | ID: mdl-25709106

Subject(s)

Autoantibodies/immunology; Hippocampus/metabolism; Long-Term Potentiation; Lupus Erythematosus, Systemic/immunology; Neurons/metabolism; Ribosomal Proteins/immunology; Synaptic Transmission; Adult; Animals; Antigens, Surface; CA1 Region, Hippocampal/metabolism; CA3 Region, Hippocampal/metabolism; Dentate Gyrus/metabolism; Disease Models, Animal; Excitatory Postsynaptic Potentials; Female; Gene Knock-In Techniques; Glutamic Acid/metabolism; Humans; Lupus Erythematosus, Systemic/metabolism; Memory; Mice; Neuronal Plasticity; Neurons/immunology; Patch-Clamp Techniques; Receptors, AMPA/metabolism; Receptors, N-Methyl-D-Aspartate/metabolism; Ribosomal Proteins/metabolism; Spinal Cord/cytology; Young Adult

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribosomal Proteins / Autoantibodies / Long-Term Potentiation / Synaptic Transmission / Hippocampus / Lupus Erythematosus, Systemic / Neurons Type of study: Prognostic_studies Limits: Adult / Animals / Female / Humans Language: En Journal: Arthritis Rheumatol Year: 2015 Document type: Article

Fulltext

XML

PubMed Links

Search on Google