The effect of varying extents of Fluosol-DA or normal saline haemodilution on the dose dependent kinetics of phenytoin in the rat.
J Pharm Pharmacol
; 41(8): 582-4, 1989 Aug.
Article
in En
| MEDLINE
| ID: mdl-2571710
ABSTRACT
Phenytoin kinetics were determined in rats in which the blood was moderately haemodiluted with 20 or 40 mL kg-1 of Fluosol-DA or normal saline. Rats received one of three intravenous phenytoin doses (10, 40, 50 mg kg-1) 0.5, 24, 48, or 72 h after haemodilution and were compared with non-exchanged controls. Haemodilution with either 20 or 40 mL kg-1 of Fluosol or saline had no influence on the dose-dependent kinetics of phenytoin. Haemodilution with 40 mL kg-1 of Fluosol decreased the half-life of phenytoin's major metabolite, HPPH, after a 50 mg kg-1 dose. Neither Fluosol nor saline haemodilution affected the normal delay in biliary cycling of HPPH.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenytoin
/
Blood Substitutes
/
Fluorocarbons
Limits:
Animals
Language:
En
Journal:
J Pharm Pharmacol
Year:
1989
Document type:
Article