Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice.

Williams, Jessica A; Ni, Hong-Min; Haynes, Anna; Manley, Sharon; Li, Yuan; Jaeschke, Hartmut; Ding, Wen-Xing

Williams, Jessica A; Ni, Hong-Min; Haynes, Anna; Manley, Sharon; Li, Yuan; Jaeschke, Hartmut; Ding, Wen-Xing.

Affiliation

Williams JA; From the Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Ni HM; From the Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Haynes A; From the Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Manley S; From the Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Li Y; From the Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Jaeschke H; From the Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Ding WX; From the Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 wxding@kumc.edu.

J Biol Chem ; 290(17): 10934-46, 2015 Apr 24.

Article in En | MEDLINE | ID: mdl-25752611

Subject(s)

Acetaminophen/adverse effects; Analgesics, Non-Narcotic/adverse effects; Chemical and Drug Induced Liver Injury; Gene Deletion; Mitophagy; Ubiquitin-Protein Ligases/deficiency; Acetaminophen/pharmacology; Analgesics, Non-Narcotic/pharmacology; Animals; Cell Proliferation/drug effects; Cell Proliferation/genetics; Chemical and Drug Induced Liver Injury/genetics; Chemical and Drug Induced Liver Injury/metabolism; Chemical and Drug Induced Liver Injury/pathology; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Gene Knockdown Techniques; Hepatocytes/metabolism; Hepatocytes/pathology; Liver/metabolism; Liver/pathology; Mice; Mice, Knockout; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Mitophagy/drug effects; Mitophagy/genetics; Myeloid Cell Leukemia Sequence 1 Protein/biosynthesis; Myeloid Cell Leukemia Sequence 1 Protein/genetics; Ubiquitination/drug effects; Ubiquitination/genetics

Key words

Acetaminophen; Autophagy; Cell Death; Liver Injury; Mitochondria; Mitophagy

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Gene Deletion / Analgesics, Non-Narcotic / Ubiquitin-Protein Ligases / Chemical and Drug Induced Liver Injury / Mitophagy / Acetaminophen Limits: Animals Language: En Journal: J Biol Chem Year: 2015 Document type: Article

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