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Oral administration of non-absorbable delayed release 6-mercaptopurine is locally active in the gut, exerts a systemic immune effect and alleviates Crohn's disease with low rate of side effects: results of double blind Phase II clinical trial.
Israeli, E; Goldin, E; Fishman, S; Konikoff, F; Lavy, A; Chowers, Y; Melzer, E; Lahat, A; Mahamid, M; Shirin, H; Nussinson, E; Segol, O; Ya'acov, A Ben; Shabbat, Y; Ilan, Y.
Affiliation
  • Israeli E; Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem.
  • Goldin E; Department of Gastroenterology, Shaarei Zedek Medical Center, Jerusalem.
  • Fishman S; Department of Gastroenterology, Tel Aviv-Sourasky Medical Center, Tel Aviv.
  • Konikoff F; Department of Gastroenterology, Meir Medical Center, Kfar Saba.
  • Lavy A; Department of Gastroenterology, Bnai Zion Hospital, Haifa.
  • Chowers Y; Department of Gastroenterology, Rambam Health Care Campus and Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa.
  • Melzer E; Department of Gastroenterology, Kaplan Medical Center, Rehovot.
  • Lahat A; Department of Gastroenterology, Sheba Medical Center, Tel Hashomer.
  • Mahamid M; Department of Gastroenterology, Holy Family Hospital, Nazareth.
  • Shirin H; Department of Gastroenterology, Assaf Harofeh Medical Center, Zerifin.
  • Nussinson E; Department of Gastroenterology, Ha'emek Medical Center, Afula.
  • Segol O; Department of Gastroenterology, Carmel Medical Center, Haifa, Israel.
  • Ya'acov AB; Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem.
  • Shabbat Y; Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem.
  • Ilan Y; Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem.
Clin Exp Immunol ; 181(2): 362-72, 2015 Aug.
Article in En | MEDLINE | ID: mdl-25846055
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gastrointestinal Agents / Crohn Disease / Delayed-Action Preparations / Mercaptopurine / Antimetabolites Type of study: Clinical_trials Language: En Journal: Clin Exp Immunol Year: 2015 Document type: Article
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gastrointestinal Agents / Crohn Disease / Delayed-Action Preparations / Mercaptopurine / Antimetabolites Type of study: Clinical_trials Language: En Journal: Clin Exp Immunol Year: 2015 Document type: Article