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The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.
Chung, Jacky; Bauer, Daniel E; Ghamari, Alireza; Nizzi, Christopher P; Deck, Kathryn M; Kingsley, Paul D; Yien, Yvette Y; Huston, Nicholas C; Chen, Caiyong; Schultz, Iman J; Dalton, Arthur J; Wittig, Johannes G; Palis, James; Orkin, Stuart H; Lodish, Harvey F; Eisenstein, Richard S; Cantor, Alan B; Paw, Barry H.
Affiliation
  • Chung J; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Bauer DE; Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Ghamari A; Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Nizzi CP; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
  • Deck KM; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
  • Kingsley PD; Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA.
  • Yien YY; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Huston NC; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Chen C; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Schultz IJ; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Dalton AJ; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Wittig JG; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Palis J; Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA.
  • Orkin SH; Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Lodish HF; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Eisenstein RS; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
  • Cantor AB; Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Paw BH; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Bos
Sci Signal ; 8(372): ra34, 2015 Apr 14.
Article in En | MEDLINE | ID: mdl-25872869
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Hemoglobins / Carrier Proteins / Eukaryotic Initiation Factors / Multiprotein Complexes / TOR Serine-Threonine Kinases / Leucine Type of study: Prognostic_studies Language: En Journal: Sci Signal Year: 2015 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Hemoglobins / Carrier Proteins / Eukaryotic Initiation Factors / Multiprotein Complexes / TOR Serine-Threonine Kinases / Leucine Type of study: Prognostic_studies Language: En Journal: Sci Signal Year: 2015 Document type: Article