St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins.

Sehirli, A O; Cetinel, S; Ozkan, N; Selman, S; Tetik, S; Yuksel, M; Dulger, F G A

Sehirli, A O; Cetinel, S; Ozkan, N; Selman, S; Tetik, S; Yuksel, M; Dulger, F G A.

Affiliation

Sehirli AO; Department of Pharmacology, Marmara University School of Pharmacy, Istanbul, Turkey. fgdulger45@gmail.com.

J Physiol Pharmacol ; 66(2): 203-14, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25903951

Subject(s)

ATP Binding Cassette Transporter, Subfamily B/metabolism; Colitis, Ulcerative/drug therapy; Hypericum/chemistry; Plant Extracts/pharmacology; Receptors, Steroid/metabolism; Trinitrobenzenesulfonic Acid/pharmacology; Animals; Anti-Inflammatory Agents/pharmacology; Antioxidants/pharmacology; Colitis, Ulcerative/blood; Colitis, Ulcerative/metabolism; Cytochrome P-450 Enzyme System/metabolism; Inflammatory Bowel Diseases/blood; Inflammatory Bowel Diseases/drug therapy; Inflammatory Bowel Diseases/metabolism; Male; NF-kappa B/blood; Oxidative Stress/drug effects; Peroxidase/metabolism; Pregnane X Receptor; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spironolactone/pharmacology; Tumor Necrosis Factor-alpha/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Trinitrobenzenesulfonic Acid / Plant Extracts / Colitis, Ulcerative / Receptors, Steroid / ATP Binding Cassette Transporter, Subfamily B / Hypericum Limits: Animals Language: En Journal: J Physiol Pharmacol Year: 2015 Document type: Article

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