Anti-inflammatory anthraquinones from the crinoid Himerometra magnipinna.
Nat Prod Commun
; 10(2): 317-8, 2015 Feb.
Article
in En
| MEDLINE
| ID: mdl-25920272
ABSTRACT
Chemical investigation of a crinoid Himerometra magnipinna has afforded three anthraquinones (1-3), including one new metabolite, (+)-rhodoptilometrin (1). The structures of these compounds were elucidated on the basis of their spectroscopic data and the absolute configuration of 1 was further confirmed by single-crystal X-ray diffraction analysis. In the in vitro anti-inflammatory effects test, compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anthraquinones
/
Echinodermata
/
Anti-Inflammatory Agents
Limits:
Animals
Language:
En
Journal:
Nat Prod Commun
Year:
2015
Document type:
Article