Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors.

Iglarz, Marc; Steiner, Pauline; Wanner, Daniel; Rey, Markus; Hess, Patrick; Clozel, Martine

Iglarz, Marc; Steiner, Pauline; Wanner, Daniel; Rey, Markus; Hess, Patrick; Clozel, Martine.

Affiliation

Iglarz M; Drug Discovery Department, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.

J Cardiovasc Pharmacol ; 66(4): 332-7, 2015 Oct.

Article in En | MEDLINE | ID: mdl-25992919

Subject(s)

Endothelin A Receptor Antagonists/pharmacology; Endothelin B Receptor Antagonists/pharmacology; Hypertension, Pulmonary/drug therapy; Receptor, Endothelin A/metabolism; Receptor, Endothelin B/metabolism; Vasodilation/drug effects; Animals; Aorta, Thoracic/drug effects; Aorta, Thoracic/metabolism; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Endothelium, Vascular/physiopathology; Hypertension, Pulmonary/metabolism; In Vitro Techniques; Nitric Oxide/metabolism; Pulmonary Artery/drug effects; Pulmonary Artery/metabolism; Rats, Inbred Dahl; Rats, Wistar; Vasoconstriction/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasodilation / Receptor, Endothelin A / Receptor, Endothelin B / Endothelin A Receptor Antagonists / Endothelin B Receptor Antagonists / Hypertension, Pulmonary Limits: Animals Language: En Journal: J Cardiovasc Pharmacol Year: 2015 Document type: Article

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