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(-)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-ß aggregation with high antioxidant potency for Alzheimer's therapy.
Cheng, Shaobing; Zheng, Wei; Gong, Ping; Zhou, Qiang; Xie, Qiong; Yu, Lining; Zhang, Peiyi; Chen, Liangkang; Li, Juan; Chen, Jianxing; Chen, Hailin; Chen, Hongzhuan.
Affiliation
  • Cheng S; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, PR China.
  • Zheng W; NPFPC Key Laboratory of Contraceptives Drugs & Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, PR China. Electronic address: zhengwei726@126.com.
  • Gong P; Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, PR China.
  • Zhou Q; Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medical, 164 Lanxi Road, Shanghai 200062, PR China.
  • Xie Q; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, PR China.
  • Yu L; NPFPC Key Laboratory of Contraceptives Drugs & Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, PR China.
  • Zhang P; NPFPC Key Laboratory of Contraceptives Drugs & Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, PR China.
  • Chen L; NPFPC Key Laboratory of Contraceptives Drugs & Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, PR China.
  • Li J; Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, PR China. Electronic address: lijuanpharm@gmail.com.
  • Chen J; NPFPC Key Laboratory of Contraceptives Drugs & Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, PR China.
  • Chen H; NPFPC Key Laboratory of Contraceptives Drugs & Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, PR China.
  • Chen H; Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, PR China.
Bioorg Med Chem ; 23(13): 3110-8, 2015 Jul 01.
Article in En | MEDLINE | ID: mdl-26025073
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Cholinesterase Inhibitors / Amyloid beta-Peptides / Neuroprotective Agents / Melatonin / Meptazinol / Antioxidants Limits: Humans Language: En Journal: Bioorg Med Chem Year: 2015 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Cholinesterase Inhibitors / Amyloid beta-Peptides / Neuroprotective Agents / Melatonin / Meptazinol / Antioxidants Limits: Humans Language: En Journal: Bioorg Med Chem Year: 2015 Document type: Article