AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1&#945; and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol.

Chen, Shuyang; Yin, Chengqian; Lao, Taotao; Liang, Dongming; He, Dan; Wang, Chenguang; Sang, Nianli

AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol.

Chen, Shuyang; Yin, Chengqian; Lao, Taotao; Liang, Dongming; He, Dan; Wang, Chenguang; Sang, Nianli.

Affiliation

Chen S; a Department of Biology and Graduate Program of Biological Sciences; CoAS; Department of Pathology & Laboratory Medicine; DUCOM; Drexel University ; Philadelphia , PA USA.

Cell Cycle ; 14(15): 2520-36, 2015 Aug 03.

Article in En | MEDLINE | ID: mdl-26061431

Subject(s)

AMP-Activated Protein Kinases/metabolism; HSP70 Heat-Shock Proteins/metabolism; Histone Deacetylases/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation/genetics; Cell Survival/genetics; Cytosol/metabolism; Enzyme Activation; HeLa Cells; Histone Deacetylases/metabolism; Humans; MCF-7 Cells; RNA Interference; RNA, Small Interfering

Key words

AMPK; HDAC5; HIF-1; Hsp70; deacetylation; nuclear export

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HSP70 Heat-Shock Proteins / Hypoxia-Inducible Factor 1, alpha Subunit / AMP-Activated Protein Kinases / Histone Deacetylases Limits: Humans Language: En Journal: Cell Cycle Year: 2015 Document type: Article

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