[The relation of abstinence analgesia to the development of cardiac disorders in the ethanol withdrawal syndrome in rats]. / Sviaz' abstinentnoi anal'gezii s razvitiem kardial'nykh narushenii pri sindrome otmena étanola u krys.
Biull Eksp Biol Med
; 108(9): 274-6, 1989 Sep.
Article
in Ru
| MEDLINE
| ID: mdl-2611381
ABSTRACT
Ethanol was administrated intragastrically (25%, w/v) to Wistar male rats. They received 7-10 g ethanol/kg b.wt. daily in 2 fractional doses for 6 days. In 20-24 hours after the last ethanol administration behavioral and neurological signs of withdrawal syndrome and pain latent period were measured. Analgesia was determined using the tail flick and hot plate tests. Two days later systolic function of the isolated perfusing heart and creatine phosphokinase outflow were examined. Rats had longer latent pain period than in control. Heart perfusion revealed a decrease of systolic pressure, dp/dt of systolic and diastolic pressure, increase of enzyme outflow. Kendall's correlation analysis revealed a positive relationship between intensity of withdrawal symptoms and analgesia index in the hot plate test (tau = +0.343, p. 0.01) and a lack of relationship in the tail flick test. There was negative relationship between the analgesia index and the indices of heart disorders. It is proposed that analgesia index can be used as a predictor of the cardiac muscle injury caused by the alcoholic abstinent syndrome.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain
/
Substance Withdrawal Syndrome
/
Cardiomyopathy, Alcoholic
/
Ethanol
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Ru
Journal:
Biull Eksp Biol Med
Year:
1989
Document type:
Article