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The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.
Tu, Chi-Chiang; Zhong, Yan; Nguyen, Louis; Tsai, Aaron; Sridevi, Priya; Tarn, Woan-Yuh; Wang, Jean Y J.
Affiliation
  • Tu CC; Moores Cancer Center and Division of Hematology-Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0644, USA. Institute of Biomedical Sciences, Academia Sinica, Taipei 11529 Taiwan.
  • Zhong Y; Moores Cancer Center and Division of Hematology-Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0644, USA.
  • Nguyen L; Moores Cancer Center and Division of Hematology-Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0644, USA.
  • Tsai A; Moores Cancer Center and Division of Hematology-Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0644, USA.
  • Sridevi P; Moores Cancer Center and Division of Hematology-Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0644, USA.
  • Tarn WY; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529 Taiwan.
  • Wang JY; Moores Cancer Center and Division of Hematology-Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0644, USA. jywang@ucsd.edu.
Sci Signal ; 8(383): ra64, 2015 Jun 30.
Article in En | MEDLINE | ID: mdl-26126715
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / RNA Processing, Post-Transcriptional / Oncogene Proteins v-abl / RNA-Binding Proteins / MicroRNAs Limits: Animals / Humans Language: En Journal: Sci Signal Year: 2015 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / RNA Processing, Post-Transcriptional / Oncogene Proteins v-abl / RNA-Binding Proteins / MicroRNAs Limits: Animals / Humans Language: En Journal: Sci Signal Year: 2015 Document type: Article