The hypothalamic transcriptional response to stress is severely impaired in offspring exposed to adverse nutrition during gestation.

Grissom, N M; George, R; Reyes, T M

Grissom, N M; George, R; Reyes, T M.

Affiliation

Grissom NM; University of Cincinnati, College of Medicine, Department of Psychiatry and Behavioral Neurosciences, 2120 East Galbraith Road, A-129, Cincinnati, OH 45237-1625, United States.
George R; University of Cincinnati, College of Medicine, Department of Psychiatry and Behavioral Neurosciences, 2120 East Galbraith Road, A-129, Cincinnati, OH 45237-1625, United States.
Reyes TM; University of Cincinnati, College of Medicine, Department of Psychiatry and Behavioral Neurosciences, 2120 East Galbraith Road, A-129, Cincinnati, OH 45237-1625, United States. Electronic address: reyesta@ucmail.uc.edu.

Neuroscience ; 342: 200-211, 2017 02 07.

Article in En | MEDLINE | ID: mdl-26215917

Subject(s)

Diet, High-Fat/adverse effects; Diet, Protein-Restricted/adverse effects; Hypothalamus/growth & development; Hypothalamus/metabolism; Prenatal Nutritional Physiological Phenomena; Stress, Psychological/metabolism; Animals; Circadian Rhythm/physiology; Corticosterone/metabolism; Disease Models, Animal; Female; Gene Expression Regulation/physiology; Glucocorticoids; Male; Mice, Inbred C57BL; Mice, Inbred DBA; Pregnancy; Stress, Physiological/physiology; Transcription, Genetic/physiology

Key words

HPA; gene expression; hypothalamus; maternal diet; stress; transcription

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Psychological / Diet, Protein-Restricted / Prenatal Nutritional Physiological Phenomena / Diet, High-Fat / Hypothalamus Type of study: Prognostic_studies Limits: Animals / Pregnancy Language: En Journal: Neuroscience Year: 2017 Document type: Article

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