Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles.
Sci Rep
; 5: 12842, 2015 Aug 04.
Article
in En
| MEDLINE
| ID: mdl-26239953
ABSTRACT
Visualizing the movement of angiocatheters during endovascular interventions is typically accomplished using x-ray fluoroscopy. There are many potential advantages to developing magnetic resonance imaging-based approaches that will allow three-dimensional imaging of the tissue/vasculature interface while monitoring other physiologically-relevant criteria, without exposing the patient or clinician team to ionizing radiation. Here we introduce a proof-of-concept development of a magnetic resonance imaging-guided catheter tracking method that utilizes hyperpolarized silicon particles. The increased signal of the silicon particles is generated via low-temperature, solid-state dynamic nuclear polarization, and the particles retain their enhanced signal for ≥ 40 minutes--allowing imaging experiments over extended time durations. The particles are affixed to the tip of standard medical-grade catheters and are used to track passage under set distal and temporal points in phantoms and live mouse models. With continued development, this method has the potential to supplement x-ray fluoroscopy and other MRI-guided catheter tracking methods as a zero-background, positive contrast agent that does not require ionizing radiation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Silicon
/
Magnetic Resonance Imaging
/
Fluoroscopy
/
Contrast Media
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Sci Rep
Year:
2015
Document type:
Article