Heritability and familiality of neurological soft signs: evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives.
Psychol Med
; 46(1): 117-23, 2016 Jan.
Article
in En
| MEDLINE
| ID: mdl-26347209
ABSTRACT
BACKGROUND:
Neurological soft signs (NSS) have long been considered potential endophenotypes for schizophrenia. However, few studies have investigated the heritability and familiality of NSS. The present study examined the heritability and familiality of NSS in healthy twins and patient-relative pairs.METHOD:
The abridged version of the Cambridge Neurological Inventory was administered to 267 pairs of monozygotic twins, 124 pairs of dizygotic twins, and 75 pairs of patients with schizophrenia and their non-psychotic first-degree relatives.RESULTS:
NSS were found to have moderate but significant heritability in the healthy twin sample. Moreover, patients with schizophrenia correlated closely with their first-degree relatives on NSS.CONCLUSIONS:
Taken together, the findings provide evidence on the heritability and familiality of NSS in the Han Chinese population.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Sensation Disorders
/
Motor Skills Disorders
/
Diseases in Twins
/
Endophenotypes
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Psychol Med
Year:
2016
Document type:
Article