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Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.
Cendret, V; Legigan, T; Mingot, A; Thibaudeau, S; Adachi, I; Forcella, M; Parenti, P; Bertrand, J; Becq, F; Norez, C; Désiré, J; Kato, A; Blériot, Y.
Affiliation
  • Cendret V; Université de Poitiers, IC2MP, UMR CNRS 7285 Equipe"Synthèse Organique"4 rue Michel Brunet, 86073 Poitiers cedex 09, France. Jerome.desire@univ-poitiers.fr yves.bleriot@univ-poitiers.fr.
  • Legigan T; Université de Poitiers, IC2MP, UMR CNRS 7285 Equipe"Synthèse Organique"4 rue Michel Brunet, 86073 Poitiers cedex 09, France. Jerome.desire@univ-poitiers.fr yves.bleriot@univ-poitiers.fr.
  • Mingot A; Université de Poitiers, IC2MP, UMR CNRS 7285 Equipe"Synthèse Organique"4 rue Michel Brunet, 86073 Poitiers cedex 09, France. Jerome.desire@univ-poitiers.fr yves.bleriot@univ-poitiers.fr.
  • Thibaudeau S; Université de Poitiers, IC2MP, UMR CNRS 7285 Equipe"Synthèse Organique"4 rue Michel Brunet, 86073 Poitiers cedex 09, France. Jerome.desire@univ-poitiers.fr yves.bleriot@univ-poitiers.fr.
  • Adachi I; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. kato@med.u-toyama.ac.jp.
  • Forcella M; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza del Scienza 2, 20126 Milano, Italy.
  • Parenti P; Department of Earth and Environmental Sciences, University of Milano-Bicocca, Piazza del Scienza 1, 20126 Milano, Italy.
  • Bertrand J; Laboratoire STIM Signalisation et Transports Ioniques Membranaires, ERL7368 (0864)- CNRS/Université de Poitiers, TSA 51106 - 1, rue Georges Bonnet, 86073 Poitiers Cedex 9, France.
  • Becq F; Laboratoire STIM Signalisation et Transports Ioniques Membranaires, ERL7368 (0864)- CNRS/Université de Poitiers, TSA 51106 - 1, rue Georges Bonnet, 86073 Poitiers Cedex 9, France.
  • Norez C; Laboratoire STIM Signalisation et Transports Ioniques Membranaires, ERL7368 (0864)- CNRS/Université de Poitiers, TSA 51106 - 1, rue Georges Bonnet, 86073 Poitiers Cedex 9, France.
  • Désiré J; Université de Poitiers, IC2MP, UMR CNRS 7285 Equipe"Synthèse Organique"4 rue Michel Brunet, 86073 Poitiers cedex 09, France. Jerome.desire@univ-poitiers.fr yves.bleriot@univ-poitiers.fr.
  • Kato A; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. kato@med.u-toyama.ac.jp.
  • Blériot Y; Université de Poitiers, IC2MP, UMR CNRS 7285 Equipe"Synthèse Organique"4 rue Michel Brunet, 86073 Poitiers cedex 09, France. Jerome.desire@univ-poitiers.fr yves.bleriot@univ-poitiers.fr.
Org Biomol Chem ; 13(43): 10734-44, 2015 Nov 21.
Article in En | MEDLINE | ID: mdl-26356422
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trehalase / 1-Deoxynojirimycin / Cystic Fibrosis Transmembrane Conductance Regulator / Enzyme Inhibitors / Glycoside Hydrolase Inhibitors Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Org Biomol Chem Year: 2015 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trehalase / 1-Deoxynojirimycin / Cystic Fibrosis Transmembrane Conductance Regulator / Enzyme Inhibitors / Glycoside Hydrolase Inhibitors Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Org Biomol Chem Year: 2015 Document type: Article