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Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
Mazur, Pawel K; Herner, Alexander; Mello, Stephano S; Wirth, Matthias; Hausmann, Simone; Sánchez-Rivera, Francisco J; Lofgren, Shane M; Kuschma, Timo; Hahn, Stephan A; Vangala, Deepak; Trajkovic-Arsic, Marija; Gupta, Aayush; Heid, Irina; Noël, Peter B; Braren, Rickmer; Erkan, Mert; Kleeff, Jörg; Sipos, Bence; Sayles, Leanne C; Heikenwalder, Mathias; Heßmann, Elisabeth; Ellenrieder, Volker; Esposito, Irene; Jacks, Tyler; Bradner, James E; Khatri, Purvesh; Sweet-Cordero, E Alejandro; Attardi, Laura D; Schmid, Roland M; Schneider, Guenter; Sage, Julien; Siveke, Jens T.
Affiliation
  • Mazur PK; Department of Pediatrics, Stanford University School of Medicine, California, USA.
  • Herner A; Department of Genetics, Stanford University School of Medicine, California, USA.
  • Mello SS; Second Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Wirth M; Department of Genetics, Stanford University School of Medicine, California, USA.
  • Hausmann S; Department of Radiation Oncology, Stanford University School of Medicine, California, USA.
  • Sánchez-Rivera FJ; Second Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Lofgren SM; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Kuschma T; David H. Koch Institute for Integrative Cancer Research, Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Hahn SA; Department of Medicine, Stanford University School of Medicine, California, USA.
  • Vangala D; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, California, USA.
  • Trajkovic-Arsic M; Department of Pediatrics, Stanford University School of Medicine, California, USA.
  • Gupta A; Department of Genetics, Stanford University School of Medicine, California, USA.
  • Heid I; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.
  • Noël PB; Ruhr-University Bochum, Medical Clinic, Knappschaftskrankenhaus, Bochum, Germany.
  • Braren R; Second Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Erkan M; Second Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Kleeff J; Institute of Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Sipos B; Institute of Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Sayles LC; Institute of Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Heikenwalder M; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Heßmann E; Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Ellenrieder V; Institute of Pathology, University of Tübingen, Tübingen, Germany.
  • Esposito I; Department of Pediatrics, Stanford University School of Medicine, California, USA.
  • Jacks T; Institute of Virology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Bradner JE; Division of Chronic Inflammation and Cancer, German Cancer Research center (DKFZ) Heidelberg, Germany.
  • Khatri P; Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Göttingen, Germany.
  • Sweet-Cordero EA; Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Göttingen, Germany.
  • Attardi LD; Institute of Pathology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Schmid RM; David H. Koch Institute for Integrative Cancer Research, Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Schneider G; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
  • Sage J; Department of Medicine, Stanford University School of Medicine, California, USA.
  • Siveke JT; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, California, USA.
Nat Med ; 21(10): 1163-71, 2015 Oct.
Article in En | MEDLINE | ID: mdl-26390243
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma / Proteins / Carcinoma, Pancreatic Ductal / Epigenesis, Genetic / Histone Deacetylase Inhibitors Limits: Animals / Humans Language: En Journal: Nat Med Year: 2015 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma / Proteins / Carcinoma, Pancreatic Ductal / Epigenesis, Genetic / Histone Deacetylase Inhibitors Limits: Animals / Humans Language: En Journal: Nat Med Year: 2015 Document type: Article