Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors.
Nucleosides Nucleotides Nucleic Acids
; 34(11): 763-85, 2015.
Article
in En
| MEDLINE
| ID: mdl-26398773
ABSTRACT
Ribose modified 1'-C-cyano pyrimidine nucleosides were synthesized. A silver triflate mediated Vorbrüggen reaction was used to generate the nucleoside scaffold and follow-up chemistry provided specific ribose modified analogs. Nucleosides and phosphoramidate prodrugs were tested for their anti-HCV activity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrimidine Nucleosides
/
DNA-Directed RNA Polymerases
/
Hepacivirus
/
Enzyme Inhibitors
Language:
En
Journal:
Nucleosides Nucleotides Nucleic Acids
Year:
2015
Document type:
Article