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Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors.
Kirschberg, Thorsten A; Mish, Michael; Squires, Neil H; Zonte, Sebastian; Aktoudianakis, Evangelos; Metobo, Sammy; Butler, Thomas; Ju, Xie; Cho, Aesop; Ray, Adrian S; Kim, Choung U.
Affiliation
  • Kirschberg TA; a Medicinal Chemistry, Gilead Sciences , Foster City , CA , USA.
  • Mish M; a Medicinal Chemistry, Gilead Sciences , Foster City , CA , USA.
  • Squires NH; a Medicinal Chemistry, Gilead Sciences , Foster City , CA , USA.
  • Zonte S; a Medicinal Chemistry, Gilead Sciences , Foster City , CA , USA.
  • Aktoudianakis E; a Medicinal Chemistry, Gilead Sciences , Foster City , CA , USA.
  • Metobo S; a Medicinal Chemistry, Gilead Sciences , Foster City , CA , USA.
  • Butler T; a Medicinal Chemistry, Gilead Sciences , Foster City , CA , USA.
  • Ju X; a Medicinal Chemistry, Gilead Sciences , Foster City , CA , USA.
  • Cho A; a Medicinal Chemistry, Gilead Sciences , Foster City , CA , USA.
  • Ray AS; a Medicinal Chemistry, Gilead Sciences , Foster City , CA , USA.
  • Kim CU; b Kainos Medicine, Inc. , Seoul , Republic of Korea.
Nucleosides Nucleotides Nucleic Acids ; 34(11): 763-85, 2015.
Article in En | MEDLINE | ID: mdl-26398773
ABSTRACT
Ribose modified 1'-C-cyano pyrimidine nucleosides were synthesized. A silver triflate mediated Vorbrüggen reaction was used to generate the nucleoside scaffold and follow-up chemistry provided specific ribose modified analogs. Nucleosides and phosphoramidate prodrugs were tested for their anti-HCV activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidine Nucleosides / DNA-Directed RNA Polymerases / Hepacivirus / Enzyme Inhibitors Language: En Journal: Nucleosides Nucleotides Nucleic Acids Year: 2015 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidine Nucleosides / DNA-Directed RNA Polymerases / Hepacivirus / Enzyme Inhibitors Language: En Journal: Nucleosides Nucleotides Nucleic Acids Year: 2015 Document type: Article