Cationic Cobalt(III)-Catalyzed Aryl and Alkenyl C-H Amidation: A Mild Protocol for the Modification of Purine Derivatives.
Chemistry
; 21(46): 16395-9, 2015 Nov 09.
Article
in En
| MEDLINE
| ID: mdl-26418889
ABSTRACT
A cationic cobalt(III)-catalyzed direct C-H amidation of unactivated (hetero)arenes and alkenes by using 1,4,2-dioxazol-5-ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant-free conditions with a broad substrate scope. Moreover, 6-arylpurine compounds, which often exhibit high potency in antimycobacterial, cytostatic, and anti-HCV activities, can be smoothly amidated, thus offering a mild protocol for their late stage functionalization.
Full text:
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chemistry
Year:
2015
Document type:
Article