Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function.

Mitson-Salazar, Alyssa; Yin, Yuzhi; Wansley, Daniel L; Young, Michael; Bolan, Hyejeong; Arceo, Sarah; Ho, Nancy; Koh, Christopher; Milner, Joshua D; Stone, Kelly D; Wank, Stephen A; Prussin, Calman

Mitson-Salazar, Alyssa; Yin, Yuzhi; Wansley, Daniel L; Young, Michael; Bolan, Hyejeong; Arceo, Sarah; Ho, Nancy; Koh, Christopher; Milner, Joshua D; Stone, Kelly D; Wank, Stephen A; Prussin, Calman.

Affiliation

Mitson-Salazar A; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Yin Y; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Wansley DL; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Young M; Clinical Research Directorate/CMRP, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Md.
Bolan H; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Arceo S; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Ho N; Gastroenterology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md.
Koh C; Gastroenterology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md.
Milner JD; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Stone KD; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Wank SA; Gastroenterology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md.
Prussin C; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: calmanp@gmail.com.

J Allergy Clin Immunol ; 137(3): 907-18.e9, 2016 Mar.

Article in En | MEDLINE | ID: mdl-26431580

Subject(s)

Eosinophils/immunology; Eosinophils/metabolism; Intramolecular Oxidoreductases/metabolism; Lipocalins/metabolism; Th2 Cells/immunology; Th2 Cells/metabolism; Animals; Biomarkers; Cell Differentiation; Cell Line; Cytokines/metabolism; Disease Models, Animal; Humans; Hypersensitivity/immunology; Hypersensitivity/metabolism; Immunity, Innate; Immunologic Memory; Immunophenotyping; Interleukin-5/metabolism; Mice; NK Cell Lectin-Like Receptor Subfamily B/metabolism; Phenotype; Receptors, CCR/metabolism; Receptors, Lymphocyte Homing/metabolism; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism; Th2 Cells/cytology

Key words

Atopic dermatitis; CD161; CD294; CD4; IL-5; T(H)2; chemoattractant receptorhomologous molecule expressed on T(H)2 cells; eosinophilic gastrointestinal disease; eosinophilic inflammation; hematopoietic prostaglandin D synthase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Th2 Cells / Intramolecular Oxidoreductases / Eosinophils / Lipocalins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Allergy Clin Immunol Year: 2016 Document type: Article

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