Variability of Forebrain Commissures in Callosal Agenesis: A Prenatal MR Imaging Study.
AJNR Am J Neuroradiol
; 37(3): 521-7, 2016 Mar.
Article
in En
| MEDLINE
| ID: mdl-26514610
ABSTRACT
BACKGROUND AND PURPOSE:
Agenesis of the corpus callosum, even when isolated, may be characterized by anatomic variability. The aim of this study was to describe the types of other forebrain commissures in a large cohort of randomly enrolled fetuses with apparently isolated agenesis of the corpus callosum at prenatal MR imaging. MATERIALS ANDMETHODS:
All fetuses with apparent isolated agenesis of the corpus callosum undergoing prenatal MR imaging from 2004 to 2014, were evaluated for the presence of the anterior or a vestigial hippocampal commissure assessed in consensus by 2 pediatric neuroradiologists.RESULTS:
Overall, 62 cases of agenesis of the corpus callosum were retrieved from our data base. In 3/62 fetuses (4.8%), no forebrain commissure was visible at prenatal MR imaging, 23/62 fetuses (37.1%) presented with only the anterior commissure, and 20/62 fetuses (32.3%) showed both the anterior commissure and a residual vestigial hippocampal commissure, whereas in the remaining 16/62 fetuses (25.8%), a hybrid structure merging a residual vestigial hippocampal commissure and a rudiment of the corpus callosum body was detectable. Postnatal MR imaging, when available, confirmed prenatal forebrain commissure findings.CONCLUSIONS:
Most fetuses with apparent isolated agenesis of the corpus callosum showed at least 1 forebrain commissure at prenatal MR imaging, and approximately half of fetuses also had a second commissure a vestigial hippocampal commissure or a hybrid made of a hippocampal commissure and a rudimentary corpus callosum body. Whether such variability is the result of different genotypes and whether it may have any impact on the long-term neurodevelopmental outcome remains to be assessed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fornix, Brain
/
Agenesis of Corpus Callosum
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
AJNR Am J Neuroradiol
Year:
2016
Document type:
Article