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The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.
Albesa-Jové, David; Comino, Natalia; Tersa, Montse; Mohorko, Elisabeth; Urresti, Saioa; Dainese, Elisa; Chiarelli, Laurent R; Pasca, Maria Rosalia; Manganelli, Riccardo; Makarov, Vadim; Riccardi, Giovanna; Svergun, Dmitri I; Glockshuber, Rudi; Guerin, Marcelo E.
Affiliation
  • Albesa-Jové D; From the Unidad de Biofísica, Centro Mixto Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC,UPV/EHU), Barrio Sarriena s/n, Leioa, Bizkaia 48940, Spain, the Departamento de Bioquímica, Universidad del País Vasco, Leioa, Bizkaia 48940, Spa
  • Comino N; From the Unidad de Biofísica, Centro Mixto Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC,UPV/EHU), Barrio Sarriena s/n, Leioa, Bizkaia 48940, Spain, the Departamento de Bioquímica, Universidad del País Vasco, Leioa, Bizkaia 48940, Spa
  • Tersa M; From the Unidad de Biofísica, Centro Mixto Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC,UPV/EHU), Barrio Sarriena s/n, Leioa, Bizkaia 48940, Spain, the Departamento de Bioquímica, Universidad del País Vasco, Leioa, Bizkaia 48940, Spa
  • Mohorko E; the Institute for Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland.
  • Urresti S; From the Unidad de Biofísica, Centro Mixto Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC,UPV/EHU), Barrio Sarriena s/n, Leioa, Bizkaia 48940, Spain, the Departamento de Bioquímica, Universidad del País Vasco, Leioa, Bizkaia 48940, Spa
  • Dainese E; the Departments of Molecular Medicine and.
  • Chiarelli LR; Biology and Biotechnology "Lazzaro Spallanzani," University of Pavia, 27100 Pavia, Italy.
  • Pasca MR; Biology and Biotechnology "Lazzaro Spallanzani," University of Pavia, 27100 Pavia, Italy.
  • Manganelli R; the Departments of Molecular Medicine and.
  • Makarov V; the A. N. Bakh Institute of Biochemistry, Russian Academy of Science, 119071 Moscow, Russia, and.
  • Riccardi G; Biology and Biotechnology "Lazzaro Spallanzani," University of Pavia, 27100 Pavia, Italy.
  • Svergun DI; the European Molecular Biology Laboratory, Hamburg Outstation, c/o Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, D-22603 Hamburg, Germany.
  • Glockshuber R; the Institute for Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland.
  • Guerin ME; From the Unidad de Biofísica, Centro Mixto Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC,UPV/EHU), Barrio Sarriena s/n, Leioa, Bizkaia 48940, Spain, the Departamento de Bioquímica, Universidad del País Vasco, Leioa, Bizkaia 48940, Spa
J Biol Chem ; 290(52): 31077-89, 2015 Dec 25.
Article in En | MEDLINE | ID: mdl-26546681
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Bacterial Proteins / Prodrugs / Models, Molecular / Protein Multimerization / Mycobacterium tuberculosis / Antitubercular Agents Language: En Journal: J Biol Chem Year: 2015 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Bacterial Proteins / Prodrugs / Models, Molecular / Protein Multimerization / Mycobacterium tuberculosis / Antitubercular Agents Language: En Journal: J Biol Chem Year: 2015 Document type: Article