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Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.
van der Westhuyzen, Renier; Winks, Susan; Wilson, Colin R; Boyle, Grant A; Gessner, Richard K; Soares de Melo, Candice; Taylor, Dale; de Kock, Carmen; Njoroge, Mathew; Brunschwig, Christel; Lawrence, Nina; Rao, Srinivasa P S; Sirgel, Frederick; van Helden, Paul; Seldon, Ronnett; Moosa, Atica; Warner, Digby F; Arista, Luca; Manjunatha, Ujjini H; Smith, Paul W; Street, Leslie J; Chibale, Kelly.
Affiliation
  • van der Westhuyzen R; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Winks S; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Wilson CR; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Boyle GA; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Gessner RK; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Soares de Melo C; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Taylor D; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town , Observatory 7925, South Africa.
  • de Kock C; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town , Observatory 7925, South Africa.
  • Njoroge M; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Brunschwig C; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Lawrence N; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Rao SP; Novartis Institute for Tropical Diseases (NITD) , 10 Biopolis Road, Chromos no. 05-01, Singapore 138670, Singapore.
  • Sirgel F; DST/NRF Centre of Excellence in Biomedical TB Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University , Tygerberg 7505, South Africa.
  • van Helden P; DST/NRF Centre of Excellence in Biomedical TB Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University , Tygerberg 7505, South Africa.
  • Seldon R; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
  • Moosa A; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology, University of Cape Town , Rondebosch 7701, South Africa.
  • Warner DF; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology, University of Cape Town , Rondebosch 7701, South Africa.
  • Arista L; Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Rondebosch 7701, South Africa.
  • Manjunatha UH; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Smith PW; Novartis Institute for Tropical Diseases (NITD) , 10 Biopolis Road, Chromos no. 05-01, Singapore 138670, Singapore.
  • Street LJ; Novartis Institute for Tropical Diseases (NITD) , 10 Biopolis Road, Chromos no. 05-01, Singapore 138670, Singapore.
  • Chibale K; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.
J Med Chem ; 58(23): 9371-81, 2015 Dec 10.
Article in En | MEDLINE | ID: mdl-26551248
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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 / 3_ND Database: MEDLINE Main subject: Pyrroles / Electron Transport Complex III / Mycobacterium tuberculosis / Antitubercular Agents Limits: Animals / Humans Language: En Journal: J Med Chem Year: 2015 Document type: Article
Fulltext
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XML
PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 / 3_ND Database: MEDLINE Main subject: Pyrroles / Electron Transport Complex III / Mycobacterium tuberculosis / Antitubercular Agents Limits: Animals / Humans Language: En Journal: J Med Chem Year: 2015 Document type: Article