Fibulin-4 deficiency increases TGF-ß signalling in aortic smooth muscle cells due to elevated TGF-ß2 levels.

Ramnath, N W M; Hawinkels, L J A C; van Heijningen, P M; te Riet, L; Paauwe, M; Vermeij, M; Danser, A H J; Kanaar, R; ten Dijke, P; Essers, J

Ramnath, N W M; Hawinkels, L J A C; van Heijningen, P M; te Riet, L; Paauwe, M; Vermeij, M; Danser, A H J; Kanaar, R; ten Dijke, P; Essers, J.

Affiliation

Ramnath NW; Department of Genetics, Cancer Genomics Centre Netherlands, Erasmus MC, Rotterdam, The Netherlands.
Hawinkels LJ; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.
van Heijningen PM; Department of Molecular Cell Biology Leiden University Medical Centre, Leiden, The Netherlands, Cancer Genomics Centre.
te Riet L; Department of Gastroenterology-Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.
Paauwe M; Department of Genetics, Cancer Genomics Centre Netherlands, Erasmus MC, Rotterdam, The Netherlands.
Vermeij M; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.
Danser AH; Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands.
Kanaar R; Department of Molecular Cell Biology Leiden University Medical Centre, Leiden, The Netherlands, Cancer Genomics Centre.
ten Dijke P; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Essers J; Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands.

Sci Rep ; 5: 16872, 2015 Nov 26.

Article in En | MEDLINE | ID: mdl-26607280

Subject(s)

Aorta/cytology; Extracellular Matrix Proteins/deficiency; Myocytes, Smooth Muscle/metabolism; Signal Transduction; Transforming Growth Factor beta1/metabolism; Transforming Growth Factor beta2/metabolism; Animals; Aorta, Thoracic/metabolism; Cell Proliferation; Extracellular Matrix Proteins/metabolism; Human Umbilical Vein Endothelial Cells/metabolism; Humans; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Transforming Growth Factor beta2/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Signal Transduction / Extracellular Matrix Proteins / Myocytes, Smooth Muscle / Transforming Growth Factor beta1 / Transforming Growth Factor beta2 Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2015 Document type: Article

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