Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage.

John, Constance M; Phillips, Nancy J; Din, Richard; Liu, Mingfeng; Rosenqvist, Einar; Høiby, E Arne; Stein, Daniel C; Jarvis, Gary A

John, Constance M; Phillips, Nancy J; Din, Richard; Liu, Mingfeng; Rosenqvist, Einar; Høiby, E Arne; Stein, Daniel C; Jarvis, Gary A.

Affiliation

John CM; From the Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California 94121, the Departments of Laboratory Medicine and.
Phillips NJ; the Departments of Laboratory Medicine and.
Din R; From the Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California 94121.
Liu M; From the Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California 94121, the Departments of Laboratory Medicine and.
Rosenqvist E; the Norwegian Institute of Public Health, P. O. Box 4404, Nydalen, 0403 Oslo, Norway, and.
Høiby EA; the Norwegian Institute of Public Health, P. O. Box 4404, Nydalen, 0403 Oslo, Norway, and.
Stein DC; the Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742.
Jarvis GA; From the Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, California 94121, the Departments of Laboratory Medicine and gary.jarvis@ucsf.edu.

J Biol Chem ; 291(7): 3224-38, 2016 Feb 12.

Article in En | MEDLINE | ID: mdl-26655715

Subject(s)

Antigens, Bacterial/toxicity; Carrier State/microbiology; Lipopolysaccharides/toxicity; Meningitis, Meningococcal/microbiology; Meningococcal Infections/microbiology; Neisseria meningitidis, Serogroup B/pathogenicity; Neisseria meningitidis, Serogroup C/pathogenicity; Acylation; Adolescent; Antigens, Bacterial/biosynthesis; Antigens, Bacterial/chemistry; Carrier State/blood; Carrier State/cerebrospinal fluid; Carrier State/immunology; Cell Line, Tumor; Computational Biology; Gene Expression Profiling; Humans; Immunity, Innate/drug effects; Lipopolysaccharides/biosynthesis; Lipopolysaccharides/chemistry; Meningitis, Meningococcal/blood; Meningitis, Meningococcal/cerebrospinal fluid; Meningitis, Meningococcal/immunology; Meningococcal Infections/blood; Meningococcal Infections/cerebrospinal fluid; Meningococcal Infections/immunology; Molecular Structure; Monocytes/drug effects; Monocytes/immunology; Monocytes/metabolism; Neisseria meningitidis, Serogroup B/classification; Neisseria meningitidis, Serogroup B/immunology; Neisseria meningitidis, Serogroup B/metabolism; Neisseria meningitidis, Serogroup C/classification; Neisseria meningitidis, Serogroup C/immunology; Neisseria meningitidis, Serogroup C/metabolism; Norway; Phosphorylation; Sepsis/blood; Sepsis/cerebrospinal fluid; Sepsis/immunology; Sepsis/microbiology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Necrosis Factor-alpha/metabolism; Virulence

Key words

Neisseria meningitidis; acylation; bioinformatics; infection; lipid A; lipooligosaccharide; mass spectrometry (MS); phosphoethanolamine; phosphorylation; sialic acid

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Carrier State / Lipopolysaccharides / Neisseria meningitidis, Serogroup B / Neisseria meningitidis, Serogroup C / Meningitis, Meningococcal / Meningococcal Infections / Antigens, Bacterial Country/Region as subject: Europa Language: En Journal: J Biol Chem Year: 2016 Document type: Article

Fulltext

XML

PubMed Links

Search on Google