Prediction of Type II Toxin-Antitoxin Loci in Klebsiella pneumoniae Genome Sequences.
Interdiscip Sci
; 8(2): 143-149, 2016 Jun.
Article
in En
| MEDLINE
| ID: mdl-26662948
ABSTRACT
Klebsiella pneumoniae is an increasingly important bacterial pathogen to human. This Gram-negative bacterium species has become a serious concern due to its dramatic increase in the levels of multiple antibiotic resistances, particularly to carbapenems. The toxin-antitoxin (TA) system has recently been reported to be involved in the formation of drug-tolerant persister cells. The type II TA system is composed of a stable toxin protein and a relatively unstable antitoxin protein that is able to inhibit the toxin. Here, we examine the type II TA locus distribution and compare the TA diversity throughout ten completely sequenced K. pneumoniae genomes by using bioinformatics approaches. Two hundred and twelve putative type II TA loci were identified in 30 replicons of these K. pneumoniae strains. The amino acid sequence similarity-based grouping shows that these loci distribute differently not only among different K. pneumoniae strains isolated from diverse sources, but also between their chromosomes and plasmids.
Key words
Full text:
1
Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
Bacterial Proteins
/
Genome, Bacterial
/
Klebsiella pneumoniae
Type of study:
Prognostic_studies
/
Risk_factors_studies
Language:
En
Journal:
Interdiscip Sci
Year:
2016
Document type:
Article