BAY 81-8973 safety and efficacy for prophylaxis and treatment of bleeds in previously treated children with severe haemophilia A: results of the LEOPOLD Kids Trial.

Ljung, R; Kenet, G; Mancuso, M E; Kaleva, V; Rusen, L; Tseneklidou-Stoeter, D; Michaels, L A; Shah, A; Hong, W; Maas Enriquez, M

Ljung, R; Kenet, G; Mancuso, M E; Kaleva, V; Rusen, L; Tseneklidou-Stoeter, D; Michaels, L A; Shah, A; Hong, W; Maas Enriquez, M.

Affiliation

Ljung R; Department of Clinical Sciences Lund-Pediatrics, Malmö Centre for Thrombosis and Haemostasis, Skåne University Hospital, Lund University, Malmö, Sweden.
Kenet G; Chaim Sheba Medical Center, The Israeli National Hemophilia Center, The Sackler Medical School, Tel Aviv University, Tel-Hashomer, Israel.
Mancuso ME; Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Kaleva V; MHAT Sveta Marina, Clinic of Pediatric Hematology and Oncology, Varna, Bulgaria.
Rusen L; SC Sanador SRL, Bucharest, Romania.
Tseneklidou-Stoeter D; Bayer Pharma AG, Berlin, Germany.
Michaels LA; Bayer HealthCare Pharmaceuticals, Whippany, NJ, USA.
Shah A; Bayer HealthCare Pharmaceuticals, Whippany, NJ, USA.
Hong W; Bayer HealthCare Pharmaceuticals, Whippany, NJ, USA.
Maas Enriquez M; Bayer Pharma AG, Wuppertal, Germany.

Haemophilia ; 22(3): 354-60, 2016 May.

Article in En | MEDLINE | ID: mdl-26663410

Subject(s)

Coagulants/therapeutic use; Factor VIII/therapeutic use; Hemophilia A/drug therapy; Area Under Curve; Child; Child, Preschool; Coagulants/adverse effects; Coagulants/pharmacokinetics; Factor VIII/adverse effects; Factor VIII/pharmacokinetics; Half-Life; Hemophilia A/pathology; Hemorrhage/prevention & control; Humans; Infant; Male; ROC Curve; Severity of Illness Index; Treatment Outcome

Key words

children; clinical trial; factor VIII; haemophilia A; prophylaxis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Factor VIII / Coagulants / Hemophilia A Type of study: Clinical_trials / Prognostic_studies Limits: Child / Child, preschool / Humans / Infant / Male Language: En Journal: Haemophilia Year: 2016 Document type: Article

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