Your browser doesn't support javascript.
loading
Asthma as a risk factor for zoster in adults: A population-based case-control study.
Kwon, Hyo Jin; Bang, Duk Won; Kim, Eun Na; Wi, Chung-Il; Yawn, Barbara P; Wollan, Peter C; Lahr, Brian D; Ryu, Euijung; Juhn, Young J.
Affiliation
  • Kwon HJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Department of Pediatrics, College of Medicine, Catholic University of Korea, Seoul, Korea.
  • Bang DW; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
  • Kim EN; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
  • Wi CI; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn.
  • Yawn BP; Department of Research, Olmsted Medical Center, Rochester, Minn.
  • Wollan PC; Department of Research, Olmsted Medical Center, Rochester, Minn.
  • Lahr BD; Department of Health Sciences Research, Mayo Clinic, Rochester, Minn.
  • Ryu E; Department of Health Sciences Research, Mayo Clinic, Rochester, Minn.
  • Juhn YJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Department of Health Sciences Research, Mayo Clinic, Rochester, Minn; Department of Internal Medicine, Mayo Clinic, Rochester, Minn. Electronic address: juhn.young@mayo.edu.
J Allergy Clin Immunol ; 137(5): 1406-12, 2016 05.
Article in En | MEDLINE | ID: mdl-26739414
BACKGROUND: We recently reported an increased risk of herpes zoster (shingles or zoster) in children with asthma, but little is known about whether the same is true for adults with asthma. OBJECTIVE: We determined whether asthma is associated with an increased risk of zoster in adults. METHODS: This study was designed as a population-based case-control study. Zoster cases during the study period were identified among adults (aged ≥50 years) who resided in Olmsted County, Minnesota. We compared the frequency of asthma between zoster cases and birthday- and sex-matched control subjects (1:2 matching) without a history of zoster. Asthma status was ascertained based on predetermined criteria. A conditional logistic regression model was used to assess the association of asthma with risk of zoster. RESULTS: A total of 371 zoster cases and their 742 matched control subjects were enrolled. Of the 371 cases, 246 (66%) were female, 348 (94%) were white, and the mean ± SD age was 66.8 ± 10.7 years. Twenty-three percent (n = 87) of zoster cases had a history of asthma compared with 15% (n = 114) of control subjects. Controlling for pertinent covariates and confounders, there was a significant association between a history of asthma and risk of zoster (adjusted odds ratio, 1.70; 95% CI, 1.20-2.42; P = .003). The population attributable risk percentage for asthma was about 10%. CONCLUSIONS: Asthma is an unrecognized risk factor for zoster in adults. Consideration should be given to immunizing adults with asthma aged more than 50 years as a target group.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 2_ODS3 Database: MEDLINE Main subject: Asthma / Herpes Zoster Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: America do norte Language: En Journal: J Allergy Clin Immunol Year: 2016 Document type: Article

Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 2_ODS3 Database: MEDLINE Main subject: Asthma / Herpes Zoster Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: America do norte Language: En Journal: J Allergy Clin Immunol Year: 2016 Document type: Article