Oxidative stress contributes to the enhanced expression of Gq&#945;/PLCß1 proteins and hypertrophy of VSMC from SHR: role of growth factor receptor transactivation.

Atef, Mohammed Emehdi; Anand-Srivastava, Madhu B

Oxidative stress contributes to the enhanced expression of Gqα/PLCß1 proteins and hypertrophy of VSMC from SHR: role of growth factor receptor transactivation.

Atef, Mohammed Emehdi; Anand-Srivastava, Madhu B.

Affiliation

Atef ME; Department of Molecular and Integrative Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
Anand-Srivastava MB; Department of Molecular and Integrative Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada madhu.anand-srivastava@umontreal.ca.

Am J Physiol Heart Circ Physiol ; 310(5): H608-18, 2016 Mar 01.

Article in En | MEDLINE | ID: mdl-26747500

Subject(s)

GTP-Binding Protein alpha Subunits, Gq-G11/metabolism; Hypertension/enzymology; Muscle, Smooth, Vascular/enzymology; Myocytes, Smooth Muscle/enzymology; Oxidative Stress; Phospholipase C beta/metabolism; Receptors, Growth Factor/metabolism; Animals; Antioxidants/pharmacology; Cell Size; Cells, Cultured; Disease Models, Animal; ErbB Receptors/metabolism; Hypertension/genetics; Hypertension/pathology; Hypertrophy; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinases/metabolism; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/pathology; Myocytes, Smooth Muscle/drug effects; Myocytes, Smooth Muscle/pathology; Oxidative Stress/drug effects; Phosphorylation; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins pp60(c-src)/antagonists & inhibitors; Proto-Oncogene Proteins pp60(c-src)/metabolism; RNA Interference; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, IGF Type 1/metabolism; Receptors, Growth Factor/antagonists & inhibitors; Receptors, Growth Factor/genetics; Receptors, Platelet-Derived Growth Factor/metabolism; Signal Transduction; Transfection; Up-Regulation

Key words

Gqα/PLCß1; SHR; VSMC; hypertrophy; oxidative stress

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Growth Factor / Oxidative Stress / Myocytes, Smooth Muscle / GTP-Binding Protein alpha Subunits, Gq-G11 / Phospholipase C beta / Hypertension / Muscle, Smooth, Vascular Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Year: 2016 Document type: Article

Fulltext

XML

PubMed Links

Search on Google