The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.

Berge, T; Leikfoss, I S; Brorson, I S; Bos, S D; Page, C M; Gustavsen, M W; Bjølgerud, A; Holmøy, T; Celius, E G; Damoiseaux, J; Smolders, J; Harbo, H F; Spurkland, A

Berge, T; Leikfoss, I S; Brorson, I S; Bos, S D; Page, C M; Gustavsen, M W; Bjølgerud, A; Holmøy, T; Celius, E G; Damoiseaux, J; Smolders, J; Harbo, H F; Spurkland, A.

Affiliation

Berge T; Department of Neurology, Oslo University Hospital, Oslo, Norway.
Leikfoss IS; Department of Neurology, Oslo University Hospital, Oslo, Norway.
Brorson IS; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Bos SD; Department of Neurology, Oslo University Hospital, Oslo, Norway.
Page CM; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Gustavsen MW; Department of Neurology, Oslo University Hospital, Oslo, Norway.
Bjølgerud A; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Holmøy T; Department of Neurology, Oslo University Hospital, Oslo, Norway.
Celius EG; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Damoiseaux J; Department of Neurology, Oslo University Hospital, Oslo, Norway.
Smolders J; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Harbo HF; Department of Neurology, Oslo University Hospital, Oslo, Norway.
Spurkland A; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Genes Immun ; 17(2): 118-27, 2016 Mar.

Article in En | MEDLINE | ID: mdl-26765264

Subject(s)

CD4-Positive T-Lymphocytes/drug effects; GTPase-Activating Proteins/genetics; Interleukin-2 Receptor alpha Subunit/genetics; Multiple Sclerosis/genetics; Receptors, Calcitriol/genetics; Vitamin D/pharmacology; Adult; CD4-Positive T-Lymphocytes/metabolism; CD4-Positive T-Lymphocytes/pathology; Female; GTPase-Activating Proteins/agonists; GTPase-Activating Proteins/blood; Gene Expression; Gene Expression Profiling; Genetic Predisposition to Disease; Humans; Interleukin-2 Receptor alpha Subunit/antagonists & inhibitors; Interleukin-2 Receptor alpha Subunit/blood; Male; Middle Aged; Multiple Sclerosis/blood; Multiple Sclerosis/pathology; Polymorphism, Single Nucleotide; Primary Cell Culture; Receptors, Calcitriol/blood; Response Elements; Vitamin D/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vitamin D / CD4-Positive T-Lymphocytes / Receptors, Calcitriol / GTPase-Activating Proteins / Interleukin-2 Receptor alpha Subunit / Multiple Sclerosis Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Genes Immun Year: 2016 Document type: Article

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