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A case of dysgraphia induced by sertraline and a review of official spontaneous adverse reaction databases.
Gentili, M; Marinaccio, P M; Galimberti, C; Carnovale, C; Antoniazzi, S; Pozzi, M; Clementi, E; Viganò, C; Radice, S.
Affiliation
  • Gentili M; Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, 'Luigi Sacco' University Hospital, Università di Milano, Milan, Italy.
  • Marinaccio PM; Psychiatry Unit, Department of Biomedical and Clinical Sciences, 'Luigi Sacco' University Hospital, Università di Milano, Milan, Italy.
  • Galimberti C; Psychiatry Unit, Department of Biomedical and Clinical Sciences, 'Luigi Sacco' University Hospital, Università di Milano, Milan, Italy.
  • Carnovale C; Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, 'Luigi Sacco' University Hospital, Università di Milano, Milan, Italy.
  • Antoniazzi S; Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, 'Luigi Sacco' University Hospital, Università di Milano, Milan, Italy.
  • Pozzi M; Scientific Direction, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Clementi E; Scientific Institute, IRCCS E. Medea, Lecco, Italy.
  • Viganò C; Scientific Institute, IRCCS E. Medea, Lecco, Italy.
  • Radice S; Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, Consiglio Nazionale delle Ricerche Institute of Neuroscience, University Hospital 'Luigi Sacco', Università di Milano, Milan, Italy.
J Clin Pharm Ther ; 41(1): 106-7, 2016 Feb.
Article in En | MEDLINE | ID: mdl-26792111
ABSTRACT
WHAT IS KNOWN AND

OBJECTIVES:

The occurrence of dysgraphia after sertraline intake has never been reported. The objective was to describe a case of this adverse drug reaction and present a review of similar cases held in international databases with a discussion of the possible pharmacological mechanisms. CASE

SUMMARY:

We observed a 60-year-old man who experienced resting tremors, dyskinesia and dysgraphia 2 months after a stepwise increase in sertraline dosing from 50 to 200 mg/day. WHAT IS NEW AND

CONCLUSION:

Dysgraphia is a possible adverse drug reaction to sertraline, and we suggest that inhibition of extrapyramidal dopaminergic activity might be the pharmacological mechanism.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selective Serotonin Reuptake Inhibitors / Sertraline / Agraphia Limits: Humans / Male / Middle aged Language: En Journal: J Clin Pharm Ther Year: 2016 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selective Serotonin Reuptake Inhibitors / Sertraline / Agraphia Limits: Humans / Male / Middle aged Language: En Journal: J Clin Pharm Ther Year: 2016 Document type: Article