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A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study.
Karki, Radha; Jun, Kyu-Yeon; Kadayat, Tara Man; Shin, Somin; Thapa Magar, Til Bahadur; Bist, Ganesh; Shrestha, Aarajana; Na, Younghwa; Kwon, Youngjoo; Lee, Eung-Seok.
Affiliation
  • Karki R; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
  • Jun KY; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program Ewha Womans University, Seoul 120-750, Republic of Korea.
  • Kadayat TM; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
  • Shin S; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program Ewha Womans University, Seoul 120-750, Republic of Korea.
  • Thapa Magar TB; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
  • Bist G; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
  • Shrestha A; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
  • Na Y; College of Pharmacy, Cha University, Pochon 487-010, Republic of Korea.
  • Kwon Y; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program Ewha Womans University, Seoul 120-750, Republic of Korea. Electronic address: ykwon@ewha.ac.kr.
  • Lee ES; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea. Electronic address: eslee@yu.ac.kr.
Eur J Med Chem ; 113: 228-45, 2016 May 04.
Article in En | MEDLINE | ID: mdl-26945111
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / DNA Topoisomerases, Type II / DNA Topoisomerases, Type I / Quantitative Structure-Activity Relationship / Topoisomerase I Inhibitors / Topoisomerase II Inhibitors / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2016 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / DNA Topoisomerases, Type II / DNA Topoisomerases, Type I / Quantitative Structure-Activity Relationship / Topoisomerase I Inhibitors / Topoisomerase II Inhibitors / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2016 Document type: Article