[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.
Chem Commun (Camb)
; 52(27): 4888-90, 2016 Apr 07.
Article
in En
| MEDLINE
| ID: mdl-26963495
ABSTRACT
Here we report the radiosynthesis of an endogenous redox pair, [(11)C]ascorbic acid ([(11)C]VitC) and [(11)C]dehydroascorbic acid ([(11)C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ascorbic Acid
/
Carbon Radioisotopes
/
Reactive Oxygen Species
/
Positron-Emission Tomography
Language:
En
Journal:
Chem Commun (Camb)
Year:
2016
Document type:
Article