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[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.
Carroll, V N; Truillet, C; Shen, B; Flavell, R R; Shao, X; Evans, M J; VanBrocklin, H F; Scott, P J H; Chin, F T; Wilson, D M.
Affiliation
  • Carroll VN; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94107, USA. David.M.Wilson@ucsf.edu.
Chem Commun (Camb) ; 52(27): 4888-90, 2016 Apr 07.
Article in En | MEDLINE | ID: mdl-26963495
ABSTRACT
Here we report the radiosynthesis of an endogenous redox pair, [(11)C]ascorbic acid ([(11)C]VitC) and [(11)C]dehydroascorbic acid ([(11)C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ascorbic Acid / Carbon Radioisotopes / Reactive Oxygen Species / Positron-Emission Tomography Language: En Journal: Chem Commun (Camb) Year: 2016 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ascorbic Acid / Carbon Radioisotopes / Reactive Oxygen Species / Positron-Emission Tomography Language: En Journal: Chem Commun (Camb) Year: 2016 Document type: Article