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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.
Almqvist, Helena; Axelsson, Hanna; Jafari, Rozbeh; Dan, Chen; Mateus, André; Haraldsson, Martin; Larsson, Andreas; Martinez Molina, Daniel; Artursson, Per; Lundbäck, Thomas; Nordlund, Pär.
Affiliation
  • Almqvist H; Laboratories for Chemical Biology, Karolinska Institutet, Science for Life Laboratory Stockholm, Division of Translational Medicine &Chemical Biology, Department of Medical Biochemistry &Biophysics, Karolinska Institutet, Tomtebodavägen 23A, Solna 171 65, Sweden.
  • Axelsson H; Laboratories for Chemical Biology, Karolinska Institutet, Science for Life Laboratory Stockholm, Division of Translational Medicine &Chemical Biology, Department of Medical Biochemistry &Biophysics, Karolinska Institutet, Tomtebodavägen 23A, Solna 171 65, Sweden.
  • Jafari R; Department of Medical Biochemistry &Biophysics, Division of Biophysics, Karolinska Institutet, Scheeles väg 2, Stockholm 171 77, Sweden.
  • Dan C; School of Biological Sciences, Nanyang Technological University, 61 Biopolis Drive (Proteos), Singapore 138673, Singapore.
  • Mateus A; Department of Pharmacy, Uppsala University, BMC, Box 580, Uppsala SE-751 23, Sweden.
  • Haraldsson M; Laboratories for Chemical Biology, Karolinska Institutet, Science for Life Laboratory Stockholm, Division of Translational Medicine &Chemical Biology, Department of Medical Biochemistry &Biophysics, Karolinska Institutet, Tomtebodavägen 23A, Solna 171 65, Sweden.
  • Larsson A; School of Biological Sciences, Nanyang Technological University, SBS-04s-45, 60 Nanyang Drive, Singapore 639798, Singapore.
  • Martinez Molina D; Department of Medical Biochemistry &Biophysics, Division of Biophysics, Karolinska Institutet, Scheeles väg 2, Stockholm 171 77, Sweden.
  • Artursson P; Department of Pharmacy, Uppsala University, BMC, Box 580, Uppsala SE-751 23, Sweden.
  • Lundbäck T; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, BMC, Box 580, Uppsala SE-751 23, Sweden.
  • Nordlund P; Science for Life Laboratory Drug Discovery and Development platform, Uppsala University, Uppsala SE-751 23, Sweden.
Nat Commun ; 7: 11040, 2016 Mar 24.
Article in En | MEDLINE | ID: mdl-27010513
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymidylate Synthase / Intracellular Space / Drug Evaluation, Preclinical / Enzyme Inhibitors / Fluorouracil Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Nat Commun Year: 2016 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymidylate Synthase / Intracellular Space / Drug Evaluation, Preclinical / Enzyme Inhibitors / Fluorouracil Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Nat Commun Year: 2016 Document type: Article