Transcriptomic gene-network analysis of exposure to silver nanoparticle reveals potentially neurodegenerative progression in mouse brain neural cells.

Lin, Ho-Chen; Huang, Chin-Lin; Huang, Yuh-Jeen; Hsiao, I-Lun; Yang, Chung-Wei; Chuang, Chun-Yu

Lin, Ho-Chen; Huang, Chin-Lin; Huang, Yuh-Jeen; Hsiao, I-Lun; Yang, Chung-Wei; Chuang, Chun-Yu.

Affiliation

Lin HC; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan.
Huang CL; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan.
Huang YJ; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan.
Hsiao IL; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan.
Yang CW; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan.
Chuang CY; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan. Electronic address: cychuang@mx.nthu.edu.tw.

Toxicol In Vitro ; 34: 289-299, 2016 Aug.

Article in En | MEDLINE | ID: mdl-27131904

Subject(s)

Astrocytes/drug effects; Metal Nanoparticles/toxicity; Microglia/drug effects; Neurons/drug effects; Silver/toxicity; Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/metabolism; Animals; Astrocytes/metabolism; Brain/cytology; Cell Line; Cell Line, Tumor; Gene Expression/drug effects; Gene Expression Profiling; Mice; Microglia/metabolism; Mitogen-Activated Protein Kinases/metabolism; Neurons/metabolism; Presenilin-1/genetics; Presenilin-2/genetics

Key words

Alzheimer's disease; Beta amyloid; Gene network; Neurodegenerative disease; Silver nanoparticle

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Silver / Astrocytes / Microglia / Metal Nanoparticles / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Toxicol In Vitro Year: 2016 Document type: Article

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