Src Is a Potential Therapeutic Target in Endocrine-Resistant Breast Cancer Exhibiting Low Estrogen Receptor-Mediated Transactivation.

Guest, Stephanie K; Ribas, Ricardo; Pancholi, Sunil; Nikitorowicz-Buniak, Joanna; Simigdala, Nikiana; Dowsett, Mitch; Johnston, Stephen R; Martin, Lesley-Ann

Guest, Stephanie K; Ribas, Ricardo; Pancholi, Sunil; Nikitorowicz-Buniak, Joanna; Simigdala, Nikiana; Dowsett, Mitch; Johnston, Stephen R; Martin, Lesley-Ann.

Affiliation

Guest SK; The Breast Cancer Now and Toby Robins Research Centre, Institute of Cancer Research, London, United Kingdom.
Ribas R; The Breast Cancer Now and Toby Robins Research Centre, Institute of Cancer Research, London, United Kingdom.
Pancholi S; The Breast Cancer Now and Toby Robins Research Centre, Institute of Cancer Research, London, United Kingdom.
Nikitorowicz-Buniak J; The Breast Cancer Now and Toby Robins Research Centre, Institute of Cancer Research, London, United Kingdom.
Simigdala N; The Breast Cancer Now and Toby Robins Research Centre, Institute of Cancer Research, London, United Kingdom.
Dowsett M; The Breast Cancer Now and Toby Robins Research Centre, Institute of Cancer Research, London, United Kingdom.
Johnston SR; Royal Marsden Hospital, London, United Kingdom.
Martin LA; Royal Marsden Hospital, London, United Kingdom.

PLoS One ; 11(6): e0157397, 2016.

Article in En | MEDLINE | ID: mdl-27308830

Subject(s)

Antineoplastic Agents, Hormonal/pharmacology; Dasatinib/pharmacology; Drug Resistance, Neoplasm/genetics; Gene Expression Regulation, Neoplastic; Receptors, Estrogen/genetics; src-Family Kinases/antagonists & inhibitors; CSK Tyrosine-Protein Kinase; Cell Line, Tumor; Cell Movement/drug effects; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Estradiol/analogs & derivatives; Estradiol/pharmacology; Female; Fulvestrant; Humans; MCF-7 Cells; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors; Mitogen-Activated Protein Kinase 1/genetics; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors; Mitogen-Activated Protein Kinase 3/genetics; Mitogen-Activated Protein Kinase 3/metabolism; Phosphorylation/drug effects; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; Receptors, Estrogen/metabolism; Signal Transduction; Tamoxifen/pharmacology; Transcriptional Activation; src-Family Kinases/genetics; src-Family Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Estrogen / Gene Expression Regulation, Neoplastic / Src-Family Kinases / Drug Resistance, Neoplasm / Antineoplastic Agents, Hormonal / Dasatinib Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: PLoS One Year: 2016 Document type: Article

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