[Congestive heart failure: Treatment with ultrafiltration]. / Insuffisance cardiaque congestive : place de l'ultrafiltration.
Ann Cardiol Angeiol (Paris)
; 65(4): 240-4, 2016 Sep.
Article
in Fr
| MEDLINE
| ID: mdl-27344095
ABSTRACT
INTRODUCTION:
The prevalence rate of congestive heart failure is approximately 2% in high-income countries. The aim of this study was to assess the overall benefit of ultrafiltration therapy in patients with acute or persistent congestive heart failure.METHODS:
We conducted a health technology assessment following the EUnetHTA guidelines, with systematic literature review from bibliographic medical databases, independent experts and manufacturer interviews.RESULTS:
Thirteen clinical trials and five meta-analyses were examined. In the most recent one, 608 patients were included, of which 304 received ultrafiltration therapy and 304 received intravenous loop diuretics. Ultrafiltration therapy seems to be more beneficial regarding the fluid removal and the body weight reduction, (mean difference respectively 1.44kg, IC95% [0.29; 2.59], P-value=0.01 and 1.28L [0.43; 2.12], P-value=0.003). No difference has been showed in overall mortality, renal function, hospital readmission or safety. Medico-economic studies are incomplete and contradictory.CONCLUSION:
Ultrafiltration therapy seems to be effective, most likely for patients ineligible or resistant to intravenous diuretics. But most topics remain uncertain, mainly impact on overall mortality, safety and cost-effectiveness. Given these knowledge-gaps, the generalization of ultrafiltration therapy should be examined cautiously, and conditional upon a large-scale systematic evaluation.Key words
Full text:
1
Collection:
01-internacional
Health context:
6_ODS3_enfermedades_notrasmisibles
Database:
MEDLINE
Main subject:
Hemofiltration
/
Heart Failure
Type of study:
Guideline
/
Health_technology_assessment
/
Qualitative_research
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
Fr
Journal:
Ann Cardiol Angeiol (Paris)
Year:
2016
Document type:
Article