Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection.

Wille, Timo; Neumaier, Katharina; Koller, Marianne; Ehinger, Christina; Aggarwal, Nidhi; Ashani, Yacov; Goldsmith, Moshe; Sussman, Joel L; Tawfik, Dan S; Thiermann, Horst; Worek, Franz

Wille, Timo; Neumaier, Katharina; Koller, Marianne; Ehinger, Christina; Aggarwal, Nidhi; Ashani, Yacov; Goldsmith, Moshe; Sussman, Joel L; Tawfik, Dan S; Thiermann, Horst; Worek, Franz.

Affiliation

Wille T; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany. Electronic address: timowille@bundeswehr.org.
Neumaier K; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Koller M; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Ehinger C; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Aggarwal N; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Ashani Y; Department of Biomolecular Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Goldsmith M; Department of Biomolecular Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Sussman JL; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Tawfik DS; Department of Biomolecular Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Thiermann H; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.

Toxicol Lett ; 258: 198-206, 2016 Sep 06.

Article in En | MEDLINE | ID: mdl-27397758

Subject(s)

Antidotes/administration & dosage; Mutation; Nerve Agents/toxicity; Organophosphate Poisoning/drug therapy; Organothiophosphorus Compounds/toxicity; Peptide Fragments/administration & dosage; Phosphoric Triester Hydrolases/administration & dosage; Animals; Animals, Outbred Strains; Antidotes/metabolism; Antidotes/pharmacokinetics; Antidotes/therapeutic use; Bacterial Proteins/administration & dosage; Bacterial Proteins/genetics; Bacterial Proteins/pharmacokinetics; Bacterial Proteins/therapeutic use; Bone Marrow; Guinea Pigs; Inactivation, Metabolic; Injections, Intralesional; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Male; Nerve Agents/analysis; Nerve Agents/metabolism; Organophosphate Poisoning/blood; Organophosphate Poisoning/etiology; Organophosphate Poisoning/metabolism; Organothiophosphorus Compounds/administration & dosage; Organothiophosphorus Compounds/antagonists & inhibitors; Organothiophosphorus Compounds/metabolism; Peptide Fragments/metabolism; Peptide Fragments/pharmacokinetics; Peptide Fragments/therapeutic use; Phosphoric Triester Hydrolases/genetics; Phosphoric Triester Hydrolases/pharmacokinetics; Phosphoric Triester Hydrolases/therapeutic use; Proteolysis; Pseudomonas/enzymology; Recombinant Proteins/administration & dosage; Recombinant Proteins/metabolism; Recombinant Proteins/pharmacokinetics; Recombinant Proteins/therapeutic use; Toxicokinetics

Key words

Bioscavenger; Catalytic; In vivo; Intraosseous; Nerve agents; Phosphotriesterase; Therapy; VX

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organothiophosphorus Compounds / Peptide Fragments / Phosphoric Triester Hydrolases / Organophosphate Poisoning / Nerve Agents / Mutation / Antidotes Type of study: Etiology_studies / Guideline / Prognostic_studies Language: En Journal: Toxicol Lett Year: 2016 Document type: Article

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