Pharmacokinetic-pharmacodynamic modelling of drug-induced QTc interval prolongation in man: prediction from in vitro human ether-à-go-go-related gene binding and functional inhibition assays and conscious dog studies.

Dubois, V F S; Casarotto, E; Danhof, M; Della Pasqua, O

Dubois, V F S; Casarotto, E; Danhof, M; Della Pasqua, O.

Affiliation

Dubois VF; Leiden Academic Centre for Drug Research, Division of Pharmacology, Leiden University, Leiden, The Netherlands.
Casarotto E; Leiden Academic Centre for Drug Research, Division of Pharmacology, Leiden University, Leiden, The Netherlands.
Danhof M; Leiden Academic Centre for Drug Research, Division of Pharmacology, Leiden University, Leiden, The Netherlands.
Della Pasqua O; Leiden Academic Centre for Drug Research, Division of Pharmacology, Leiden University, Leiden, The Netherlands. o.dellapasqua@ucl.ac.uk.

Br J Pharmacol ; 173(19): 2819-32, 2016 10.

Article in En | MEDLINE | ID: mdl-27427789

Subject(s)

Cisapride/pharmacokinetics; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors; Fluoroquinolones/pharmacokinetics; Long QT Syndrome/chemically induced; Models, Biological; Phenethylamines/pharmacokinetics; Sulfonamides/pharmacokinetics; Animals; Binding Sites/drug effects; Cells, Cultured; Consciousness; Dogs; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels/genetics; Ether-A-Go-Go Potassium Channels/metabolism; Humans; Male; Models, Animal; Moxifloxacin; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenethylamines / Sulfonamides / Long QT Syndrome / Cisapride / Fluoroquinolones / Ether-A-Go-Go Potassium Channels / Models, Biological Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Br J Pharmacol Year: 2016 Document type: Article

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