Use of LDH and autoimmune side effects to predict response to ipilimumab treatment.

Dick, J; Lang, N; Slynko, A; Kopp-Schneider, A; Schulz, C; Dimitrakopoulou-Strauss, A; Enk, A H; Hassel, J C

Dick, J; Lang, N; Slynko, A; Kopp-Schneider, A; Schulz, C; Dimitrakopoulou-Strauss, A; Enk, A H; Hassel, J C.

Affiliation

Dick J; Department of Dermatology & National Centre for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Lang N; Department of Dermatology & National Centre for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Slynko A; German Cancer Research Centre DKFZ, Department of Biostatistics, Heidelberg, Germany.
Kopp-Schneider A; German Cancer Research Centre DKFZ, Department of Biostatistics, Heidelberg, Germany.
Schulz C; Department of Dermatology & National Centre for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Dimitrakopoulou-Strauss A; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Centre Heidelberg, Germany.
Enk AH; Department of Dermatology & National Centre for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Hassel JC; Department of Dermatology & National Centre for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

Immunotherapy ; 8(9): 1033-44, 2016 09.

Article in En | MEDLINE | ID: mdl-27485076

Subject(s)

Antibodies, Monoclonal/therapeutic use; Autoimmune Diseases/diagnosis; Drug-Related Side Effects and Adverse Reactions/diagnosis; L-Lactate Dehydrogenase/metabolism; Melanoma/diagnosis; Skin Neoplasms/diagnosis; T-Lymphocytes/immunology; Adolescent; Adult; Aged; Aged, 80 and over; Autoimmune Diseases/mortality; Biomarkers, Pharmacological/metabolism; C-Reactive Protein/metabolism; CTLA-4 Antigen/immunology; Cell Proliferation; Drug-Related Side Effects and Adverse Reactions/mortality; Female; Humans; Ipilimumab; Lymphocyte Activation; Male; Melanoma/drug therapy; Melanoma/mortality; Middle Aged; Predictive Value of Tests; Prognosis; Retrospective Studies; Skin Neoplasms/drug therapy; Skin Neoplasms/mortality; Survival Analysis; Treatment Outcome; Young Adult

Key words

LDH; autoimmune side effects; ipilimumab; melanoma

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Autoimmune Diseases / T-Lymphocytes / Drug-Related Side Effects and Adverse Reactions / L-Lactate Dehydrogenase / Melanoma / Antibodies, Monoclonal Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Immunotherapy Year: 2016 Document type: Article

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