Drug discovery for hearing loss: Phenotypic screening of chemical compounds on primary cultures of the spiral ganglion.

Whitlon, Donna S

Whitlon, Donna S.

Affiliation

Whitlon DS; Department of Otolaryngology-Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Interdepartmental Neurosciences Program, Northwestern University, Chicago, IL, USA; Knowles Hearing Center, Northwestern University, Evanston, IL, USA. Electronic address: whitlon@northwestern.edu.

Hear Res ; 349: 177-181, 2017 06.

Article in En | MEDLINE | ID: mdl-27496256

Subject(s)

Drug Discovery/methods; Hearing Loss, Noise-Induced/drug therapy; Hearing/drug effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Methionine/pharmacology; Spiral Ganglion/drug effects; Animals; Hearing Loss, Noise-Induced/pathology; Hearing Loss, Noise-Induced/physiopathology; Humans; Neuronal Outgrowth/drug effects; Noise/adverse effects; Phenotype; Primary Cell Culture; Spiral Ganglion/pathology; Tissue Culture Techniques

Key words

Cochlea; Deafness; In vitro; Neurite; Phenotypic screening; Statins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiral Ganglion / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Drug Discovery / Hearing / Hearing Loss, Noise-Induced / Methionine Type of study: Diagnostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Hear Res Year: 2017 Document type: Article

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