Influence of silver and titanium dioxide nanoparticles on in vitro blood-brain barrier permeability.

Chen, I-Chieh; Hsiao, I-Lun; Lin, Ho-Chen; Wu, Chien-Hou; Chuang, Chun-Yu; Huang, Yuh-Jeen

Chen, I-Chieh; Hsiao, I-Lun; Lin, Ho-Chen; Wu, Chien-Hou; Chuang, Chun-Yu; Huang, Yuh-Jeen.

Affiliation

Chen IC; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: ejchen00@gmail.com.
Hsiao IL; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: ilunshiou@gmail.com.
Lin HC; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: photorice2@gmail.com.
Wu CH; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: chwu@mx.nthu.edu.tw.
Chuang CY; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: cychuang@mx.nthu.edu.tw.
Huang YJ; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. Electronic address: yjhuang@mx.nthu.edu.tw.

Environ Toxicol Pharmacol ; 47: 108-118, 2016 Oct.

Article in En | MEDLINE | ID: mdl-27664952

Subject(s)

Blood-Brain Barrier/drug effects; Metal Nanoparticles/toxicity; Silver/toxicity; Titanium/toxicity; Animals; Astrocytes/drug effects; Astrocytes/metabolism; Cell Survival/drug effects; Cells, Cultured; Claudin-5/metabolism; Coculture Techniques; Cytokines/metabolism; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Metal Nanoparticles/chemistry; Mice; Microscopy, Electron, Transmission; Permeability; Reactive Oxygen Species/metabolism; Silver/pharmacokinetics; Titanium/pharmacokinetics; Toxicity Tests/methods; Zonula Occludens-1 Protein/metabolism

Key words

In vitro blood-brain barrier; Permeability; Silver ions; Silver nanoparticles; Titanium dioxide nanoparticles

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Silver / Titanium / Blood-Brain Barrier / Metal Nanoparticles Limits: Animals Language: En Journal: Environ Toxicol Pharmacol Year: 2016 Document type: Article

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